2-Meth-oxy-quinoline-3-carbaldehyde.

In the title compound, C(11)H(9)NO(2), the quinoline ring system is essentially planar (r.m.s. deviation = 0.005 Å) and the meth-oxy and aldehyde groups are almost coplanar with it [N-C-O-C = 6.24 (19) and O-C-C-C = 0.3 (2)°]. In the crystal, mol-ecules are linked by pairs of C-H⋯O hydrogen bonds, forming centrosymmetric R(2) (2)(10) dimers. The dimers are linked via π-π inter-actions involving the pyridine and benzene rings [centroid-centroid distance = 3.639 (1) Å].

Effect of macrophage activation on plasma disposition of niosomal 3H-methotrexate in sarcoma-180 bearing mice.

Methotrexate niosomes were formed by reverse phase evaporation technique using sorbitan monostearate (Span 60) surfactant. The pharmacokinetic parameters of methotrexate (MTX) after macrophage activation via muramyl dipeptide gelatin conjugate were studied and the results compared with those obtained after free MTX and MTX niosomes without macrophage activation. In mice MTX concentrations and tumour regression were higher after macrophage activation.