ABSTRACT
INTRODUCTION: Although pharmacologic treatment remains the mainstay for treating rheumatoid arthritis, there is an increasing need for a method that biologically regenerates arthritic knee lesions as patient longevity continually increases. CASE PRESENTATION: We treated rheumatoid arthritis of the right knee in a 35-year-old female Korean patient using autologous chondrocyte implantation. Twelve months after surgery, the patient could walk without pain. CONCLUSION: Autologous chondrocyte implantation appears to be effective for treating rheumatoid arthritis of the knee.
ABSTRACT
BACKGROUND: We performed a multicenter, open, randomized, clinical study of autologous cultured osteoblast injection for long-bone fracture, to evaluate the fracture healing acceleration effect and the safety of autologous cultured osteoblasts. METHODS: Sixty-four patients with long-bone fractures were randomly divided into two groups, i.e. those who received autologous cultured osteoblast injection and those who received no treatment. The sum of the difference in the callus formation scores after four and eight weeks, was used as the first efficacy variable. RESULTS: The autologous cultured osteoblast injection group showed fracture healing acceleration of statistical significance, and there were no specific patient complications when using this treatment. CONCLUSION: Autologous cultured osteoblast injection should therefore be considered as a successful treatment option for treating long-bone fracture.
Subject(s)
Bony Callus , Fracture Healing , Fractures, Bone/surgery , Osteoblasts/transplantation , Adolescent , Adult , Aged , Alkaline Phosphatase/metabolism , Bone Marrow Cells/cytology , Bony Callus/metabolism , Bony Callus/pathology , Cell Culture Techniques , Cell Transplantation , Cells, Cultured , Collagen Type I/metabolism , Female , Fractures, Bone/metabolism , Fractures, Bone/pathology , Humans , Male , Middle Aged , Osteoblasts/cytology , Osteoblasts/metabolism , Transplantation, Autologous , Treatment Outcome , Young AdultABSTRACT
INTRODUCTION: Osteonecrosis of the femoral head is a progressive disease that leads to femoral head collapse and osteoarthritis. Our goal in treating osteonecrosis is to preserve, not to replace, the femoral head. CASE PRESENTATION: We present the case of a patient with bilateral osteonecrosis of the femoral head treated with autologous cultured osteoblast injection. CONCLUSION: Although our experience is limited to one patient, autologous cultured osteoblast transplantation appears to be effective for treating the osteonecrosis of femoral head.
ABSTRACT
STUDY DESIGN: Immunohistochemical study was done by harvesting articular cartilage of the facet joints during the decompressive surgery for spinal stenosis. OBJECTIVES: To observe the expression of estrogen receptor on the articular cartilage of the facet joints in degenerative spondylolisthesis (DS) SUMMARY OF BACKGROUND DATA: Few attempts have been made to evaluate the effect of sex-hormone, although DS is more common in females than in males. METHODS: After harvesting the articular cartilage of the facet joints in 17 DS and in 15 spinal stenosis (SS) patients, the expression of estrogen receptor and the severity of facet arthritis were observed by H-E and immunohistochemical staining, respectively. Measurements of both staining were made by using a semiquantitative analysis. RESULTS: The significantly increased expression of estrogen receptor correlated with the severity of facet arthritis (r = 0.78, P < 0.05). There was a significantly increased expression of estrogen receptor of the facet joint in DS compared with SS (P < 0.01). The histologic-histochemical grading of cartilage lesion in DS was 12.4 (SEM, 0.6), which was significantly higher than in SS (P < 0.05). CONCLUSIONS: These findings suggest that the higher expression of estrogen receptor might aggravate degenerative change of the facet articular cartilage and might also be considered one of the causative factors for DS in postmenopausal women.
