ABSTRACT
The combination of biocatalysis and transition-metal catalysis can complement synthetic gaps only in a chemical or biological process. However, the intrinsic mutual deactivation between enzymatic and chemical species is a significant challenge in a single operation. To address the above issue, we developed an encapsulated Au/carbene combined with a free amine dehydrogenase as a co-catalyst system that enables an efficient hydration/amination enantioselective cascade process to be accomplished. The mechanistic investigation discloses dual catalysis comprised of alkyne hydration, followed by a reductive amination process.
Subject(s)
Amines/chemical synthesis , Gold/chemistry , Methane/analogs & derivatives , Oxidoreductases/chemistry , Amination , Amines/chemistry , Amines/metabolism , Bacillaceae/enzymology , Gold/metabolism , Methane/chemistry , Methane/metabolism , Models, Molecular , Molecular Conformation , Oxidoreductases/metabolism , Water/chemistry , Water/metabolismABSTRACT
An integrated immobilization to encapsulate the Pd/C-coated magnetic nanoparticles within the chiral Ru/diamine-functionalized silica shell for the construction of a bifunctional magnetic catalyst is developed. This catalyst realizes a synergistic Suzuki cross-coupling/asymmetric transfer hydrogenation and a successive reduction/asymmetric transfer hydrogenation for the preparation of chiral aromatic alcohols.
