ABSTRACT
OBJECTIVE: To compare outcomes of in vitro fertilization (IVF) cycles with adequate versus inadequate response to the gonadotropin-releasing hormone (GnRH) agonist trigger rescued with the use of human chorionic gonadotropin (hCG) retrigger, and to identify risk factors associated with an inadequate trigger. DESIGN: Retrospective cohort study. SETTING: Private practice. PATIENT(S): Women at high risk for ovarian hyperstimulation syndrome who underwent an autologous IVF cycle and used GnRH agonist to trigger oocyte maturation before oocyte retrieval. INTERVENTION(S): Patients were triggered with GnRH agonist for final oocyte maturation before retrieval. Patients with an inadequate response, defined by low post-trigger serum LH and P concentrations or failure to recover oocytes after aspiration of several follicles, were retriggered with hCG. MAIN OUTCOME MEASURE(S): Number of oocytes retrieved, fertilization rate, clinical pregnancy, and live birth. RESULT(S): Two percent of patients triggered with GnRH agonist had an inadequate response and were retriggered with hCG. There was no statistically significant difference in clinical outcomes between the cycles that were retriggered with hCG and successful GnRH agonist triggers. Low body mass index, low baseline LH, and higher total dosage of gonadotropins required for stimulation were associated with an increased risk of having an inadequate response to the GnRH agonist trigger. CONCLUSION(S): A small minority of patients triggered with GnRH agonist had an inadequate response. Rescheduling of oocyte retrieval after hCG retrigger yielded similar IVF outcomes. Evaluation of trigger response based on serum LH and P concentrations is time dependent. Patient characteristics suggestive of hypothalamic hypofunction were predictive of an inadequate response to the GnRH agonist trigger.
Subject(s)
Chorionic Gonadotropin/therapeutic use , Fertility Agents, Female/therapeutic use , Gonadotropin-Releasing Hormone/agonists , Infertility/therapy , Leuprolide/therapeutic use , Oocytes/drug effects , Ovary/drug effects , Ovulation Induction/methods , Adult , Chorionic Gonadotropin/adverse effects , Female , Fertility , Fertility Agents, Female/adverse effects , Fertilization in Vitro , Humans , Infertility/diagnosis , Infertility/physiopathology , Live Birth , Luteinizing Hormone/blood , Oocyte Retrieval , Ovary/metabolism , Ovary/physiopathology , Ovulation Induction/adverse effects , Pregnancy , Pregnancy Rate , Progesterone/blood , Retreatment , Retrospective Studies , Risk Factors , Treatment FailureABSTRACT
Only 4% of initial applicants to the oocyte donor program completed the screening process and actually donated a cohort of oocytes. Medical screen-outs were more likely for women who had children, were unmarried, and were less educated, whereas psychological screen-outs were more common among younger applicants, and both younger and African-American women were more likely to withdraw without donating.
