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1.
Polymers (Basel) ; 15(20)2023 Oct 11.
Article in English | MEDLINE | ID: mdl-37896299

ABSTRACT

In this research, a self-reinforced composite material was manufactured using a single polyethylene material, and this self-reinforced composite material has excellent recyclability and is environmentally friendly compared to composite materials composed of other types of material, such as glass fiber reinforced composites (GFRP) and carbon fiber reinforced composites (CFRP). In this research, the manufactured self-reinforced composite material consists of an outer layer and an inner layer. To manufacture the outer layer, low density polyethylene (LDPE) films were laminated on high density polyethylene (HDPE) fabrics and knitted fabrics, and composite materials were prepared at various temperatures using hot stamping. A 3D printing process was utilized to manufacture the inner layer. After designing a structure with a cross-sectional shape of a triangle, circle, or hexagon, the inner layer structure was manufactured by 3D printing high-density polyethylene material. As an adhesive film for bonding the outer layer and the inner layer, a polyethylene-based self-reinforced composite material was prepared using a low-density polyethylene material. Input data for simulation of self-reinforced composite materials were obtained through tensile property analysis using a universal testing machine (UTM, Shimadzu, Kyoto, Japan), and the physical property values derived as output data and actual experimental values were obtained. As a result of the comparison, the error rate between simulation data and experimental data was 5.4% when the shape of the inner layer of self-reinforced composite material was a hexagon, 3.6% when it was a circle, and 7.8% when a triangular shape showed the highest value. Simulation in a virtual space can reduce the time and cost required for actual research and can be important data for producing high-quality products.

2.
Nat Mach Intell ; 5(8): 933-946, 2023.
Article in English | MEDLINE | ID: mdl-37615030

ABSTRACT

Parkinson's disease is a common, incurable neurodegenerative disorder that is clinically heterogeneous: it is likely that different cellular mechanisms drive the pathology in different individuals. So far it has not been possible to define the cellular mechanism underlying the neurodegenerative disease in life. We generated a machine learning-based model that can simultaneously predict the presence of disease and its primary mechanistic subtype in human neurons. We used stem cell technology to derive control or patient-derived neurons, and generated different disease subtypes through chemical induction or the presence of mutation. Multidimensional fluorescent labelling of organelles was performed in healthy control neurons and in four different disease subtypes, and both the quantitative single-cell fluorescence features and the images were used to independently train a series of classifiers to build deep neural networks. Quantitative cellular profile-based classifiers achieve an accuracy of 82%, whereas image-based deep neural networks predict control and four distinct disease subtypes with an accuracy of 95%. The machine learning-trained classifiers achieve their accuracy across all subtypes, using the organellar features of the mitochondria with the additional contribution of the lysosomes, confirming the biological importance of these pathways in Parkinson's. Altogether, we show that machine learning approaches applied to patient-derived cells are highly accurate at predicting disease subtypes, providing proof of concept that this approach may enable mechanistic stratification and precision medicine approaches in the future.

3.
Materials (Basel) ; 16(13)2023 Jun 24.
Article in English | MEDLINE | ID: mdl-37444874

ABSTRACT

Carbon aerogel is a promising material in various applications, such as water treatment, insulators, catalysts, and sensors, due to its porosity, low density, conductivity, and good chemical stability. In this study, an inexpensive carbon aerogel was prepared through lyophilization and post-pyrolysis using waste paper. However, carbon aerogel, in the form of short belts, is randomly entangled without a crosslinking agent and has weak mechanical properties, thus limiting its applications, which would otherwise be various. In this paper, a novel strategy is proposed to fabricate a PDMS-coated carbon aerogel (Aerogel@PDMS). Benefiting from microwave heating, precise PDMS coating onto the carbon frame was able to be carried out in a short amount of time. PDMS coating firmly tied the carbon microstructure, maintaining a unique aerogel property without blocking its porous structure. FE-SEM, RAMAN, XPS, and FT-IR were all used to confirm the surface change in PDMS coating. Compressible stability and water contact angle measurement showed that Aerogel@PDMS is a perspective organic solvent absorbent due to its good resilience and its hydrophobicity, and, as a result, its organic solvent absorption capacity and repeated absorption were evaluated, ultimately suggesting a promising material in oil clean-up and pollution remediation in water. Based on our experimental results, we identified elastic carbon aerogels provided by a novel coating technology. In the future, then, the developed carbon/PDMS composite can be examined as a promising option for various applications, such as environmental sensors, virus sensors, and wearable sensors.

4.
PLoS One ; 14(5): e0214493, 2019.
Article in English | MEDLINE | ID: mdl-31075102

ABSTRACT

Digital public displays installed in various locations provide valuable information for the passers-by. However, the static characteristic of the digital public display limits the consumption of the displayed content to a small area. Personal mobile devices such as smartphones are now capable of interacting with digital public displays, which enables the passers-by to "take-away" the content and consume it on-the-go. This process requires device binding, content selection, and transfer between the two devices. In this paper, we propose a device binding method which utilizes the content brightness changing pattern as a unique content ID on the public display and an illuminance sensor on the mobile to bind and transfer between two devices. We conducted performance evaluations for binding algorithm robustness in different conditions. Also comparative studies among other binding interaction methods were conducted. Our results show that our proposed method performed stably across the various conditions and overall performance in interaction completion time and error rate was similar or superior to the existing methods.


Subject(s)
Communications Media , Data Display , Lighting , Algorithms , Humans , Models, Theoretical
6.
Small ; 4(9): 1399-405, 2008 Sep.
Article in English | MEDLINE | ID: mdl-18720441

ABSTRACT

The device yield of molecular junctions has become a major issue for the practical application of molecular electronics based on a crossbar system of a metal-molecule-metal (MMM) junction. As the thickness of self-assembled monolayers (SAMs) is typically 1-2 nm, it is difficult to avoid electrical shorts due to the penetration of top metal particles into the SAMs. A simple and effective strategy for the creation of a reliable molecular junction using a thickness-controlled bilayer with a bifunctional heterostructure is presented. In the MMM device, the Au adlayer on the molecular layer is spontaneously formed with deposition of the top Au metals and the sandwiched molecular layer maintains the quality of the SAMs. This method greatly reduces electrical shorts by preventing the diffusion of the top metal electrode and offsetting the surface roughness of the bottom metal electrode, resulting in a device yield of more than 90%.


Subject(s)
Nanostructures/chemistry , Nanostructures/ultrastructure , Electrons , Gold/chemistry , Microscopy, Electron, Scanning , Molecular Structure , Organic Chemicals/chemistry , Spectrum Analysis
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