ABSTRACT
In our experiment it was observed that many pharmacologic actions of the rabbit bile were similar to those of bear bile. It was also demonstrated that the effects of the rabbit bile were more obvious than those of bear bile in positive inotropic action, sedation, antitussive action, antihistaminic action and so on.
Subject(s)
Gallbladder , Materia Medica/pharmacology , Rabbits , Ursidae , Animals , Antitussive Agents/pharmacology , Bufo bufo , Female , Gastrointestinal Motility/drug effects , Histamine Antagonists/pharmacology , Hypnotics and Sedatives/pharmacology , Lethal Dose 50 , Male , Mice , Myocardial Contraction/drug effectsABSTRACT
The Chinese rotavirus which causes epidemics of diarrhoea in adult humans was isolated in 1983. This virus, designated adult diarrhoea rotavirus (ADRV), resembles typical rotaviruses morphologically and has a genome made up of 11 discrete segments of double-stranded RNA. Because the Chinese rotavirus has a unique RNA pattern on polyacrylamide gel electrophoresis and is antigenically distinct from group A rotaviruses, it is tentatively included in group B. Infection with ADRV or ADRV-related viruses (as shown by serological study) is detected in human populations as widespread as mainland China, Hong Kong, Australia, the United States and Canada, and in some domestic animals. RNA co-electrophoresis has shown homology of isolates from 12 different outbreaks (with some minor variations at segments 10, 11, 3 and 5). cDNA probes and monoclonal antibodies have been prepared to improve the detection and further characterization of the virus.
