1.
Adv Exp Med Biol
; 611: 595-6, 2009.
Article
in English
| MEDLINE
| ID: mdl-19400326
ABSTRACT
Understanding impurity rejection in a drug substance crystallization process is valuable for establishing purity specifications for the starting materials used in the process. Impurity rejection has been determined for all known ABT-510 impurities and for many of the reasonable & conceivable impurities. Based on this study, a very high purity specification (e.g., > 99.7%) can be set for ABT-510 with a high level of confidence.