1.
ACS Comb Sci
; 15(10): 551-5, 2013 Oct 14.
Article
in English
| MEDLINE
| ID: mdl-24016144
ABSTRACT
A one-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles has been achieved by a three-component reaction of 2-aminobenzimidazoles with an aromatic aldehyde and an isocyanide. The reaction involving condensation of 2-aminobenzimidazole with an aldehyde is run under microwave activation to generate an imine intermediate under basic conditions which then undergoes [4 + 1] cycloaddition with an isocyanide.