ABSTRACT
Five limonoids isolated from the seeds of Chisocheton siamensis were tested for their antimalarial activity against Plasmodium falciparum, antimycobacterial activity against Mycobacterium tuberculosis and cytotoxic activity against NCI-H187 (human small cell lung cancer), KB (oral human epidermal carcinoma) and MCF-7 (breast cancer) cancer cell lines. All limonoids (1-5) showed inhibitory effect against Plasmodium falciparum with IC(50) values ranging from 2.06 to 6.31 microg/ml. Only azadiradione (2) exhibited strong inhibitory effect against Mycobacterium tuberculosis with the MIC of 6.25 microg/ml. Compounds 1-4 also showed cytotoxic activity against NCI-H187, KB and MCF-7 cancer cell lines and dysobinine (1) had the highest activity with IC(50) of 1.67, 3.17 and 2.15 microg/ml, respectively.
Subject(s)
Anti-Bacterial Agents/pharmacology , Antimalarials/pharmacology , Antineoplastic Agents/pharmacology , Limonins/pharmacology , Meliaceae/chemistry , Animals , Anti-Bacterial Agents/isolation & purification , Antimalarials/isolation & purification , Antineoplastic Agents/isolation & purification , Cell Line, Tumor , Humans , Limonins/isolation & purification , Mycobacterium tuberculosis/drug effects , Plant Extracts/chemistry , Plasmodium falciparum/drug effects , Seeds/chemistryABSTRACT
The molecule of the title compound, methyl 1-formyl-6-oxa-6H-indene-4-carboxylate, C(11)H(8)O(4), is planar. There are weak C--H...O intramolecular interactions and an intermolecular hydrogen bond in the structure, and these influence the crystal packing.
Subject(s)
Indenes/chemistry , Plants/chemistry , Crystallography, X-Ray , Hydrogen Bonding , Models, Molecular , Molecular Conformation , Plant Epidermis/chemistryABSTRACT
2',3'-Dihydroxy-4',6'-dimethoxchalcone and the corresponding dihydrochalcone were isolated from the leaves of Uvaria dulcis and characterized by chemical and spectral methods.
Subject(s)
Chalcone/analogs & derivatives , Chalcone/isolation & purification , Plants, Medicinal/chemistry , Chalcone/chemistry , Chalcones , Magnetic Resonance Spectroscopy , Plant Extracts/chemistry , Plant Leaves/chemistryABSTRACT
Among the biologically active compounds isolated from medicinal plants are polyamine derivatives that show antihypertensive or antitumour activity. We have used previously available reagents to modify selectively spermidine, homospermidine and spermine backbones. Chemical synthesis of several naturally occurring derivatives has been achieved by simple, efficient procedures that can be used to produce high yields. This has facilitated evaluation of the structure-activity relationships of polyamines.
