Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 6 de 6
Filter
Add more filters










Database
Language
Publication year range
1.
Dev Biol (Basel) ; 117: 33-41, 2004.
Article in English | MEDLINE | ID: mdl-15597614

ABSTRACT

There has been increased interest in Targeted Biologicals in the United States for several reasons. First, new technology is available to facilitate science-based isolate selection and manufacture. The science of Autologous/Targeted Biologicals will be discussed later in this presentation. A second reason for the increased interest in Targeted Biologicals is the fact that the livestock production methods have changed to favour herd/flock specific products controlled by a veterinarian. There have been changes in management methods such as segregated early weaning in swine, accelerated feeding and early weaning of dairy calves, and forced moulting in poultry. Herds and flocks have increased in stocking density and size. These factors stress animals and may facilitate mutation, strain variation and increased virulence of pathogens. Under these conditions, Traditional Biologicals may not be relevant to current field isolates. Many veterinarians favour vaccinating only for pathogens isolated from a herd/flock. A third reason for the increased interest in these products is that the licensing procedure for Targeted Biologicals is responsive to the needs of livestock producers. The process is abbreviated, requiring much less time and money. This allows for a more rapid response to emerging pathogens, strain variations and mutations, while facilitating the development of monovalent and multivalent products for limited markets or those for minor species.


Subject(s)
Biological Products , Biological Products/standards , Government Regulation , Polymerase Chain Reaction , Quality Control , Sequence Analysis, DNA , United States
2.
Dev Biol (Basel) ; 111: 189-93, 2002.
Article in English | MEDLINE | ID: mdl-12678240

ABSTRACT

The United States Department of Agriculture (USDA) and United States of America (USA) veterinary biologicals manufacturers, philosophically favour more humane test methods, but have limited funding to develop and implement them. Progress can be made by expanding the focus on animal tests considered for replacement, reduction and refinement (3Rs). In addition, animal usage requirements and defensive research costs can be made more reasonable, freeing resources to meet consumer needs.


Subject(s)
Animal Testing Alternatives , Drug Industry/economics , Vaccines , Animals , Humans , Pathology, Veterinary , United States , United States Department of Agriculture , Vaccines/economics
5.
Mod Vet Pract ; 61(3): 261-3, 1980 Mar.
Article in English | MEDLINE | ID: mdl-7366579

ABSTRACT

Inactivated feline parvovirus vaccine produced in a continuous feline cell line evoked a protective canine parvovirus antibody titer and prevented virus shedding following challenge in previously seronegative puppies. Post-vaccinal reactions to the vaccine were not observed in laboratory puppies vaccinated with multiple doses of vaccine or in vaccinated puppies from 5 clinics and/or animal shelters.


Subject(s)
Dog Diseases/prevention & control , Parvoviridae , Viral Vaccines , Virus Diseases/veterinary , Animals , Antibodies, Viral/analysis , Dog Diseases/immunology , Dogs , Drug Evaluation , Parvoviridae/immunology , Viral Vaccines/standards , Virus Diseases/immunology , Virus Diseases/prevention & control
6.
Mod Vet Pract ; 59(10): 755-7, 1978 Oct.
Article in English | MEDLINE | ID: mdl-216898

ABSTRACT

Singer Strain bovine virus diarrhea (BVD) modified live-virus vaccine, produced in a continuous bovine cell line using equine serum in the growth medium, evoked a high level of serum antibodies and protected against virulent challenge in vaccinated calves. Transmission of vaccinal virus from vaccinated cattle to susceptible controls did not occur when vaccinated and nonvaccinated cattle were kept in constant contact for 23 days. Postvaccinal reactions to the viral vaccine were not observed in vaccinated cattle from 10 feedlots or in cattle vaccinated with multiple doses of the experimental vaccine.


Subject(s)
Diarrhea Viruses, Bovine Viral/immunology , RNA Viruses/immunology , Viral Vaccines , Animals , Antibodies, Viral/analysis , Bovine Virus Diarrhea-Mucosal Disease/immunology , Bovine Virus Diarrhea-Mucosal Disease/prevention & control , Cattle , Neutralization Tests
SELECTION OF CITATIONS
SEARCH DETAIL
...