ABSTRACT
Preparation of microcapsules with aqueous core and polyamide walls is influenced by several factors. We improved the stability of walls and size of capsules by simultaneous variation of four factors: total ratio of polymer, ratio of amines to acid chlorides, concentration of surfactant and speed of stirring. Use of factorial design minimizes the number of experiments and permits us to know the influence of these factors and of their interactions. By increasing the ratio of amines to acid chlorides and with a low concentration of total polymer, we obtained more stable capsules. Surfactant had a negative effect on the hardness of the polymer.
Subject(s)
Drug Compounding/methods , Models, Theoretical , Regression AnalysisSubject(s)
Bronchopneumonia/diagnosis , Nocardia Infections , Adult , Bronchopneumonia/drug therapy , Bronchopneumonia/etiology , Humans , Male , Nocardia Infections/diagnosis , Nocardia Infections/drug therapy , Nocardia asteroides/isolation & purification , Sulfamethoxazole/therapeutic use , Trimethoprim/therapeutic useSubject(s)
Lung Diseases/microbiology , Nocardia Infections/microbiology , Adult , Humans , Male , Nocardia asteroidesABSTRACT
Nocardioses are unusual broncho-pneumopathies with a dangerous evolution which should be better known. They occur usually, except in case no. 1, in patients with decreased immunity. For this reason they belong to superinfection with opportunist germs. It should be kept in mind when identfying the nocardia so as to start an early specific treatment.
