[Indices of oxygen supply to the bodies of rats following blood replacement by a perfluorodecalin emulsion]. / Izuchenie pokazatelei kislorodnogo snabzheniia organizma krys pri obmennom zameschenii krovi émul'siei perftordekalina.

Complete exchange blood replacement by perfluorodecalin (PFD) emulsion containing 20 v% PFD, 5 w% polyoxyethylene-polyoxypropylene block copolymer as a surfactant and saline solution as a salt medium was performed in rats. The parameters of oxygen supply to the body in the initial state and at hematocrit levels decreased to 10, 5 and 1% were studied. It has been shown that oxygen consumption at the expense of PFD emulsion can reach values comparable with the initial ones.

[Significance of the chemical structure and composition of blood substitutes in the genesis of posttransfusion reactions]. / Znachenie khimicheskoi struktury i sostava krovezamitelei v geneze posttranfuzionnykh reaktsii

The work is concerned with an attempt to formulate grounds for the occurrence of possible posttransfusion reactions and complications as a result of transfusing blood substitutors from the group of synthetic and semisynthetic polymers, protein hydrolysates and aminoacid mixtures. Also, the classification of the reaction types, depending on ehc chemical structure and content of substitutors, is suggested. Some trends of prophylaxis against possible complications and reactions arising as a result of transfusion therapy are delineated, and certain demands are made to the content of new blood substitutors that would provide for a minimum risk in their application.