ABSTRACT
Papillon-Lefevre syndrome (PLS) is a rare autosomal recessive heterogeneous trait which is characterized by erythematous palmoplantar hyperkeratosis, early-onset periodontitis, and associated calcification of dura mater. The etiology of PLS is multifactorial with genetic, immunological, and microbial factors playing a role in etiopathogenesis. Recently identified genetic defect in PLS has been mapped to chromosome 11q14-q21, which involves mutations of cathepsin C. This paper presents a report of 2 cases of Papillon-lefevre syndrome in which diagnosis is based on clinical presentation and genetic mapping.
ABSTRACT
BACKGROUND: Obtaining predictable and aesthetic root coverage has become an important part of periodontal therapy. Several techniques have been developed to obtain these results with variable outcomes. The aim of this study was to compare and evaluate the effectiveness of acellular dermal matrix allograft (ADMA) and subepithelial connective tissue graft (SCTG) in combination with coronally positioned flap in the treatment of multiple gingival recessions in aesthetic areas. MATERIALS AND METHODS: Total 10 patients were selected for this study, aged between 18 to 40 years and were randomly assigned to one of the groups ADMA and SCTG. The clinical parameters including probing pocket depth, clinical attachment level, gingival recession, width of keratinized tissue were recorded at baseline and at 6 months after surgery and data was statistically analyzed. RESULTS: No significant differences in gingival recession reduction were noted between ADMA and gold - standard SCTG. Within limits of this clinical study, the use of ADMA may represent an acceptable alternative to the SCTG for treating gingival recession. The use of ADMA eliminates the need for the palatal donor site thus represents a less invasive surgery for treating multiple gingival recessions. CONCLUSIONS: These results suggest that ADMA may be a useful substitute instead of subepithelial connective tissue graft for root coverage.
