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J Struct Biol ; 215(3): 107993, 2023 09.
Article in English | MEDLINE | ID: mdl-37414374

ABSTRACT

Advancements in the field of cryo-electron microscopy (cryo-EM) have greatly contributed to our current understanding of virus structures and life cycles. In this review, we discuss the application of single particle cryo-electron microscopy (EM) for the structure elucidation of small enveloped icosahedral viruses, namely, alpha- and flaviviruses. We focus on technical advances in cryo-EM data collection, image processing, three-dimensional reconstruction, and refinement strategies for obtaining high-resolution structures of these viruses. Each of these developments enabled new insights into the alpha- and flavivirus architecture, leading to a better understanding of their biology, pathogenesis, immune response, immunogen design, and therapeutic development.


Subject(s)
Alphavirus , Flavivirus , Viruses , Cryoelectron Microscopy/methods , Viruses/chemistry , Image Processing, Computer-Assisted/methods
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