Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters









Database
Main subject
Language
Publication year range
1.
Cytotoxic bis-3,4-dihydro-beta-carbolines and bis-beta-carbolines.
Jiang, Wei-Qun; Charlet-Fagnère, Catherine; Sapi, Janos; Laronze, Jean-Yves; Renard, Pierre; Pfeiffer, Bruno; Léonce, Stéphane.
J Enzyme Inhib Med Chem ; 17(6): 369-74, 2002 Dec.
Article in English | MEDLINE | ID: mdl-12683671

ABSTRACT

Ten bis-beta-carboline 1, 2 and bis-3,4-dihydro-beta-carboline 3, 4 derivatives, linked between carbons 1 and 1' by a polymethylene spacer, were synthesized from bistryptamine amides 9, 10. Some of them display a micromolar IC50 towards L-1210 cells.


Subject(s)
Carbolines/chemical synthesis , Carbolines/pharmacology , Amides/chemistry , Animals , Cyclization , Drug Screening Assays, Antitumor , Inhibitory Concentration 50 , Leukemia L1210/drug therapy , Mice , Structure-Activity Relationship , Tumor Cells, Cultured
SEND TO:
Email
Export
Print
RSS
XML
SELECTION OF CITATIONS
SEARCH DETAIL