ABSTRACT
Malignant human breast tumours produced more prostaglandin-like material during homogenisation than did benign tumours or normal breast tissue. Greatest synthesis in vitro occurred with tumours associated with bone metastases, and the highest "basal" amounts tended to occur in tumours showing spread histologically. It is suggested that prostaglandins may play a part in tumour spread and growth in bone and that drugs which inhibit prostaglandin synthesis may be valuable therapeutic agents in cancer.
Subject(s)
Bone Neoplasms/pathology , Breast Neoplasms/metabolism , Neoplasm Invasiveness , Prostaglandins E/biosynthesis , Prostaglandins F/biosynthesis , Adolescent , Adult , Aged , Aspirin/therapeutic use , Bone Neoplasms/etiology , Bone Neoplasms/metabolism , Breast Neoplasms/analysis , Female , Humans , In Vitro Techniques , Middle Aged , Neoplasm Metastasis , Neoplasms/drug therapy , Prostaglandin Antagonists/therapeutic use , Prostaglandins E/analysis , Prostaglandins F/analysisSubject(s)
Brain Chemistry/drug effects , Indomethacin/pharmacology , Prostaglandins/metabolism , Animals , Female , Guinea Pigs , Male , Sex FactorsABSTRACT
Prostaglandin-like material was released from finely cut guinea-pig ileum or human intestinal mucosa during incubation with Krebs solution. The tissue inactivated some significant change in release of prostaglandin-like material when pure cholera toxin was incubated with guinea-pig ileum or human intestinal mucosa. The work is discussed in relation to the action of cholera toxin in vivo.
