[Phenylethylamine fluorides. II. Synthesis and neurobiochemistry in the rat]. / Phényléthylamines fluorées. II. Synthèse et étude neurobiochimique chez le rat.

Sixteen fluorinated phenylethylamines analogous to catecholamine were obtained by fluoration from the corresponding amino-alcohols. The biological activity of the compounds was evaluated by determining their affinity for the central adrenergic receptors of rat brain membranes and by measuring the monoamine synaptosomal uptake. These compounds significantly inhibited serotonine uptake, but they showed no affinity for amphetaminergic binding sites.

[Synthesis of N-phenylmaleimides. Kinetics of the antifibrillatory action of a derivative of procainamide]. / Synthèse des N-phénylmaléimides. Cinétique de l'action antifibrillante d'un dérivé du procainamide.

The synthesis of some N-phenylmaleimides is described. Among them, reaction of (III a) with procainamide afforded an available prodrug (III c). Antiarrhythmic activity of (III c) was compared with that of procainamide in mice.

Dipole moments and conformational equilibrium in some substituted 1-phenyl-1-fluoro-2-halogenoethanes.

Experimental dipole moments of substituted 1-phenyl-1-fluoro-2-halogenoethanes are compared with the vectorially and the theoretically calculated values using the CNDO/2 method. Results support the existence of a conformational mixture of these compounds as solutes; gauche structures are the prevailing conformations as in the related catecholamines.

[Study of benzimidazole and its derivatives. III. Radioprotective structure-activity relationship of various 2-alkyl (or 2-aryl) benzimidazoles]. / Etude du benzimidazole et de ses dérivés. III--Relation structure-activité radioprotectrice de quelques alkyl-2 (ou aryl-2) benzimidazoles.

Benzimidazoles show important radioprotecting activity. Structure-activity relationships (radioprotective activity and toxicity) are given for benzimidazole-2 derivatives.