ABSTRACT
A clinicopathologic case of an 80-year-old male patient with a single cutaneous tumor on the upper part of the left eyelid is reported. It was a grayish and pigmented mass covered with a thick keratin layer, well circumscribed, and exophytic. After surgical removal, histopathology showed that the tumor had a papillomatous pattern and was growing under a thick layer of hyperkeratosis. It was a typical squamous cell papilloma. This tumor belongs to the benign eyelid tumor group and can be found on the eyelids of elderly people.
Subject(s)
Eyelid Neoplasms/complications , Eyelid Neoplasms/pathology , Keratosis/complications , Keratosis/pathology , Papilloma/complications , Papilloma/pathology , Aged , Aged, 80 and over , Biopsy , Diagnosis, Differential , Eyelid Neoplasms/surgery , Humans , Keratosis/surgery , Male , Papilloma/surgeryABSTRACT
The authors present four cases of Merkel cells tumor of the eyelid. These cases conform to the standard clinical and histological criteria specified in the dermatological literature. Immuno-histochemical studies have been performed (specific neuron enolase, cytokeratin KL 1). Il the last case an ultrastructural study has made evident the characteristic neurosecretory granulations and intermediate filaments. Various hypothesis concerning the origin of this tumor are discussed in light of anatomical evidence.
Subject(s)
Adenocarcinoma/pathology , Eyelid Neoplasms/pathology , Adenocarcinoma/ultrastructure , Aged , Aged, 80 and over , Diagnosis, Differential , Eyelid Neoplasms/ultrastructure , Female , Humans , MaleABSTRACT
The diagnosis of sarcoidosis is established by biopsy of sarcoid tissues demonstrating non-caseating granuloma, but difficulties arise when extra pulmonary organs are involved separately. Positive histologic signs can however be found in the lung even when there are no radiologic features. Bronchoalveolar lavage and biopsies were performed in 19 patients presenting severe, strictly isolated uveitis (5 cases of anterior uveitis, 3 cases of posterior uveitis and 11 cases of panuveitis). Criteria of positivity were non-caseating granuloma and lymphocytosis. Positive signs were obtained in 6 cases (31,5%); 1 case of posterior uveitis and 5 of panuveitis. There was no case of false positive results but one false negative result. There was a lack of correlation between results of these investigations and angiotensin converting enzyme blood levels. These investigations are non-invasive in experienced hands.
Subject(s)
Lung/pathology , Sarcoidosis/pathology , Uveitis, Anterior/pathology , Uveitis/pathology , Adult , Biopsy , Bronchi , Bronchoscopy , Female , Fiber Optic Technology , Humans , Leukocyte Count , Lung Diseases/diagnosis , Lymphocytosis/etiology , Male , Peptidyl-Dipeptidase A/blood , Respiratory Function Tests , Sarcoidosis/diagnosis , Therapeutic Irrigation , Uveitis/etiology , Uveitis, Anterior/etiologyABSTRACT
Ganglioneuroblastoma a transitional tumor of sympathetic origin has not yet been described as involving orbit. It is characterized by a mixture of cells ranging from primitive neuroblast to well differentiated ganglion cells within a neurofibromatous tissue. The prognosis is uncertain, as the tumor may either undergo maturation into a ganglioneuroma or may metastasize widely and rapidly as in neuroblastoma. We may postulate a relationship between ganglioneuroblastoma and Recklinghausen's neurofibromatosis in view of the development of the tumor in conjunction with the phacomatosis.
Subject(s)
Ganglioneuroma/pathology , Neoplasms, Multiple Primary/pathology , Orbital Neoplasms/pathology , Cell Transformation, Neoplastic/pathology , Child, Preschool , Diagnosis, Differential , Ganglioneuroma/physiopathology , Ganglioneuroma/therapy , Humans , Male , Neuroblastoma/pathology , Neuroblastoma/physiopathology , Neurofibromatosis 1/pathology , Orbital Neoplasms/therapy , Prognosis , Skin Neoplasms/pathologyABSTRACT
Three patients from the same family presented hyaloretinal dysplasia (pseudoglioma) associated with osteoporosis and bone fragility. Results of clinical, ophthalmological, and radiological examinations in these three cases are described, together with those reported in the literature concerning 21 other cases of this rare autosomal-recessive affection.