ABSTRACT
Biopsies were taken from the upper and inner arm of 10 60-year-old male cigarette smokers and compared with 10 age-matched controls who were non-smokers. The mean relative area, number and thickness of the elastic fibres were significantly increased in the cigarette smokers compared to the controls. These results were confirmed using antibodies to elastin or the microfibrillar component of elastic tissue. In the smokers the broader and more fragmented elastic fibres in the skin were not as intensely stained as those of the non-smokers and the ultrastructural alterations of the elastic fibres were similar to those in solar elastosis.
Subject(s)
Elastic Tissue/pathology , Skin/pathology , Smoking/pathology , Antibodies , Elastic Tissue/ultrastructure , Elastin/analysis , Fibronectins/analysis , Forearm , Humans , Immunohistochemistry , Male , Microscopy, Electron , Middle Aged , Skin/chemistry , Skin/ultrastructure , Smoking/metabolismABSTRACT
The authors report the pathological and clinical findings in five cases of chondrosarcoma resembling chondroblastic chondrosarcomas as described by Lichtenstein and Bernstein in 1959 and, above all, clear cell chondrosarcomas as described by Unni et al. (1976). These chondrosarcomas have a double peculiarity:--topographic, for their site is often epiphyseal :--anatomica, for they associate, in the usual chondrosarcomatous sectors, areas rich in clear cells, with a rich blood supply, and in some cases a diffuse reactional osteogenesis. Although the long term prognosis is similar to that of all chondrosarcomas, their course is sometimes very slow. One should thus distinguish carefully these tumours from chondroblastomas in spite of certain topographic and radiological similarities.
Subject(s)
Bone Neoplasms/classification , Chondrosarcoma/classification , Adult , Bone Neoplasms/diagnosis , Bone Neoplasms/pathology , Bone Neoplasms/ultrastructure , Chondroblastoma/diagnosis , Chondrosarcoma/diagnosis , Chondrosarcoma/pathology , Chondrosarcoma/ultrastructure , Diagnosis, Differential , Epiphyses , Female , Humans , Male , Middle Aged , Prognosis , Time FactorsABSTRACT
In the rarely occuring vesical location the pheochromocytoma shows the usual features as well from morphological (conventional and ultrastructural) as from histochemical point of view. Biochemical examinations confirm the amount of adrenalin and noradrenalin. In connection with this case the authors discuss the problems related to the histogenesis of vesical pheochromocytomas and consider the linking up of this type of tumors to the APUD system.
