ABSTRACT
Barrett's esophagus is an acquired clinical condition in which the squamous epithelium of the distal esophagus is replaced by a columnar epithelium. The diagnosis requires histological confirmation of specialized intestinal metaplasia, in which goblet cells must be present. Barrett's esophagus is a risk factor for the development of esophageal adenocarcinoma, a tumor with an incidence and mortality have increased alarmingly in recent years in the western world. It has been estimated that the annual incidence of cancer in patients with Barrett's esophagus has increased from 0.2-2%. Once diagnosed, Barrett's esophagus is estimated to have an annual neoplastic transformation rate of 0.5% per patient. The highlights of the endoscopic diagnosis and treatment are reviewed here, as well as the screening and monitoring of this process.
Subject(s)
Adenocarcinoma/pathology , Barrett Esophagus/pathology , Esophageal Neoplasms/pathology , Esophagoscopy , Precancerous Conditions/pathology , Adenocarcinoma/epidemiology , Adenocarcinoma/surgery , Barrett Esophagus/epidemiology , Barrett Esophagus/surgery , Cell Transformation, Neoplastic/pathology , Disease Progression , Esophageal Neoplasms/epidemiology , Esophageal Neoplasms/surgery , Esophagectomy/methods , Esophagoscopy/methods , Humans , Incidence , Metaplasia , Precancerous Conditions/epidemiology , Precancerous Conditions/surgery , Predictive Value of Tests , Time Factors , Treatment OutcomeABSTRACT
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