[Serotonin syndrome: review and case series from the Swiss pharmacovigilance system]. / Syndrome sérotoninergique: mise au point et revue des cas annoncés en Suisse.

Serotonin syndrome is a potential adverse reaction to drugs increasing serotoninergic activity in the nervous system, some of them being frequently prescribed, such as antidepressant drugs. As clinical presentation is variable and often aspecific, diagnosing serotonin syndrome can be a challenge, particularly in mild cases. Serious forms can be lethal. The aim of this article is to increase practitioners awareness of this syndrome by reviewing current knowledge on physiopathology, clinical presentation and therapy. We also analyzed the 102 cases notified to Swissmedic from 1998 to 2009, focusing on patients profile and suspected drugs.

[Monitoring hypoglycemia in elderly diabetic patients: a prospective study]. / Plaidoyer pour un dépistage systématique de l'hypoglycémie du sujet âgé diabétique: une étude prospective.

Hypoglycaemia is often underestimated in the elderly diabetic patient, as clinical manifestations of hypoglycaemia in these patients are frequently atypical. This prospective study, enrolling 100 elderly diabetic patients (age: 79.3 years) shows a great incidence of hypoglycaemic events (24%) during the first day of hospitalisation in a geriatric unit. According to the results of this study, common risk factors for hypoglycaemia in the elderly (advanced age, insulin therapy, renal insufficiency, polymedication, fragility) have no significant predictive value. It appears that screening for risk factors is not enough to prevent hypoglycaemia in the elderly diabetic patient, thereby a careful monitoring of glycaemia during the first days (and nights) of hospitalisation is required. Renewed efforts at better defining appropriate therapeutic goals, taking into account the patient's life expectancy and comorbidities, will help prevent the occurrence of hypoglycaemia in the elderly diabetic patient.