New semi-analytical method for fast transcranial ultrasonic field simulation.

Objective.To optimize and ensure the safety of ultrasound brain therapy, personalized transcranial ultrasound simulations are very useful. They allow to predict the pressure field, depending on the patient skull and probe position. Most transcranial ultrasound simulations are based on numerical methods which have a long computation time and a high memory usage. The goal of this study is to develop a new semi-analytical field computation method that combines realism and computation speed.Approach.Instead of the classic ray tracing, the ultrasonic paths are computed by time of flight minimization. Then the pressure field is computed using the pencil method. This method requires a smooth and homogeneous skull model. The simulation algorithm, so-called SplineBeam, was numerically validated, by comparison with existing solvers, and experimentally validated by comparison with hydrophone measured pressure fields through anex vivohuman skull.Main results.SplineBeam simulated pressure fields were close to the experimentally measured ones, with a focus position difference of the order of the positioning error and a maximum pressure difference lower than 6.02%. In addition, for those configurations, SplineBeam computation time was lower than another simulation software, k-Wave's, by two orders of magnitude, thanks to its capacity to compute the field only at the focal spot.Significance.These results show the potential of this new method to compute fast and realistic transcranial pressure fields. The combination of this two assets makes it a promising tool for real time transcranial pressure field prediction during ultrasound brain therapy interventions.

Cytochrome P-450-mediated herb and food-drug interactions can be identified in cancer patients through patient self-reporting with a tablet application: results of a prospective observational study.

BACKGROUND: Consumption of herbs, food used as medicine and dietary supplements (HFDSs) is common in cancer patients. Herbs and food-drug interactions (HFDIs) can lead to serious adverse effects and can be prevented. We previously reviewed cytochrome P-450 (CYP)-mediated HFDI for 261 HFDSs and we classified the risk of CYP inhibition and induction on a level of evidence scale from 1 (high evidence, supported by several clinical studies) to 5 (low evidence, only limited preclinical data). PATIENTS AND METHODS: We conducted a prospective, non-interventional study (NCT04128865) to assess whether self-assessment of patients could detect HFDI classified as 'probable' (i.e. level 1, 2 or 3 of the scale) in a population of cancer patients. Patients were invited through a tablet application to report their consumption of herbs, regular CYP-interacting food consumption and dietary supplements, as well as some clinical data and cancer treatments. The patient's completion of the survey could be supervised by a health care professional or not. A prespecified threshold of 5% of HFDIs classified as 'probable' detected with the application was deemed relevant. RESULTS: Between 29 March 2018 and 22 June 2018, 143 patients completed the survey. Ninety-five patients (66%) reported at least one current systemic cancer treatment and were included in the analyses. Seventy-four patients reported an intake of at least one HFDS (77.9%), while 21 patients reported no HFDS (22.1%). Twenty-two HFDIs classified as 'probable' were found in 16 patients (16.8%) with the application, which was significantly superior to the prespecified threshold (P = 0.02). The interactions were reported with food (n = 19, 86%) more frequently than with herbs (n = 3, 14%) or with dietary supplements (no interaction reported). CONCLUSIONS: Self-assessment of HFDS interaction with cancer treatment with an application is feasible and should be considered in daily routine. Prospective interventional studies should be conducted to better assess the clinical benefits of this approach.

A system model for ultrasonic NDT based on the Physical Theory of Diffraction (PTD).

Simulation of ultrasonic Non Destructive Testing (NDT) is helpful for evaluating performances of inspection techniques and requires the modelling of waves scattered by defects. Two classical flaw scattering models have been previously usually employed and evaluated to deal with inspection of planar defects, the Kirchhoff approximation (KA) for simulating reflection and the Geometrical Theory of Diffraction (GTD) for simulating diffraction. Combining them so as to retain advantages of both, the Physical Theory of Diffraction (PTD) initially developed in electromagnetism has been recently extended to elastodynamics. In this paper a PTD-based system model is proposed for simulating the ultrasonic response of crack-like defects. It is also extended to provide good description of regions surrounding critical rays where the shear diffracted waves and head waves interfere. Both numerical and experimental validation of the PTD model is carried out in various practical NDT configurations, such as pulse echo and Time of Flight Diffraction (TOFD), involving both crack tip and corner echoes. Numerical validation involves comparison of this model with KA and GTD as well as the Finite-Element Method (FEM).

Modeling of ray paths of head waves on irregular interfaces in TOFD inspection for NDE.

The TOFD (Time of Flight Diffraction) technique is a classical ultrasonic inspection method used in ultrasonic non-destructive evaluation (NDE). This inspection technique is based on an arrangement of two probes of opposite beam directions and allows a precise positioning and a quantitative evaluation of the size of cracks contained in the inspected material thanks to their edges diffraction echoes. Among the typical phenomena arising for such an arrangement, head waves, which propagate along the specimen surface and are chronologically the first waves reaching the receiver, are notably observed. Head wave propagation on planar surfaces in TOFD configurations is well known. However, realistic inspection configurations often involve components with irregular surfaces, like steel excavated specimens. Surface irregularity is responsible for numerous effects on the scattering of bulk waves, causing the melting of surface and bulk mechanisms in the head wave propagation. In order to extend the classical ray approach on these complex cases, a generic algorithm of ray tracing between interface points (GIRT) has been designed. With respect to time of flight minimization (i.e. the Generalized Fermat's Principle), ray paths can be computed by GIRT for different natures of waves scattered by the complex surfaces or by flaws. The head wave fronts computed by GIRT are notably in good agreement with FEM simulated results. This algorithm, based on pure kinematic analysis of waves propagation, represents a first step in the future development of a complete ray theory for head waves simulation on irregular interfaces.

Simulation and data reconstruction for NDT phased array techniques.

Phased array techniques are now widely employed for industrial NDT applications in various contexts. Indeed, phased array present a great adaptability to the inspection configuration and the application of suitable delay laws allows to optimize the detection and characterization performances by taking into account the component geometry, the material characteristics, and the aim of the inspection. In addition, the amount of potential information issued from the inspection is in general greatly enhanced. It is the case when the employed method involve sequences of shots (sectorial scanning, multiple depth focusing etc) or when signals received on the different channels are stored. At last, application of electronic commutation make possible higher acquisition rates. Accompanying these advantages, it is clear that an optimal use of such techniques require the application of simulation-based algorithms at the different stages of the inspection process: When designing the probe by optimizing number and characteristics of element; When conceiving the inspection method by selecting suitable sequences of shots, computing optimized delay laws and evaluating the performances of the control in terms of zone coverage or flaw detection capabilities; When analysing the results by applying simulation-helped visualization and data reconstruction algorithms. For many years the CEA (French Atomic Energy Commission) has been being greatly involved in the development of such phased arrays simulation-based tools. In this paper, we will present recent advances of this activity and show different examples of application carried out on complex situations.

CIVA: an expertise platform for simulation and processing NDT data.

Ultrasonic modeling and simulation are more and more widely used by the different actors of industrial NDT. The applications are numerous and show a great variety: help for diagnosis, data reconstruction, performance demonstration, probe design and inspection parameters settling, virtual testing etc. The CEA (the French Atomic Energy Commission) is strongly involved in this evolution with the development of the CIVA expertise platform which gathers in the same software advanced processing and modeling tools. In the aim of fulfilling requirements of an intensive use the choice has been made to mainly adopt semi-analytical approximated methods. The wave propagation modeling is based on an integral formulation of the radiated field and applies the so-called pencil method. The modeling of beam-defect interaction and echoes formation mechanisms apply approximated theories such as Kirchhoff approximation or GTD. Over the years and with successive versions of the software, this approach is enriched by adaptations and improvements of the existing models or by new models, in order to extend the field of applicability of the simulation.

Ultrasonic non-destructive testing of pieces of complex geometry with a flexible phased array transducer

Ultrasonic non-destructive testing of components of complex geometry in the nuclear industry faces several difficulties: sensitivity variations due to unmatched contact, inaccurate localization of defects due to variations of transducer orientation, and uncovered area of the component. To improve the performances of such testing and defect characterization, we propose a new concept of ultrasonic contact phased array transducer. The phased array transducer has a flexible radiating surface able to fit the actual surface of the piece to optimize the contact and thus the sensitivity of the test. To control the transmitted field, and therefore to improve the defect characterization, a delay law optimizing algorithm is developed. To assess the capability of such a transducer, the Champ-Sons model, developed at the French Atomic Energy Commission for predicting field radiated by arbitrary transducers into pieces, has to be extended to sources directly in contact with pieces of complex geometry. The good behavior of this new type of probe predicted by computations is experimentally validated with a jointed transducer positioned on pieces of various profiles.