Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Cell Rep ; 42(1): 111968, 2023 01 31.
Article in English | MEDLINE | ID: mdl-36640305

ABSTRACT

The leap of retroviruses and coronaviruses from animal hosts to humans has led to two ongoing pandemics and tens of millions of deaths worldwide. Retrovirus and coronavirus nucleocapsid proteins have been studied extensively as potential drug targets due to their central roles in virus replication, among which is their capacity to bind their respective genomic RNAs for packaging into nascent virions. This review focuses on fundamental studies of these nucleocapsid proteins and how their intrinsic abilities to condense through liquid-liquid phase separation (LLPS) contribute to viral replication. Therapeutic targeting of these condensates and methodological advances are also described to address future questions on how phase separation contributes to viral replication.


Subject(s)
HIV-1 , Nucleocapsid Proteins , SARS-CoV-2 , Virus Replication , Humans , Coronavirus Nucleocapsid Proteins , COVID-19 , SARS-CoV-2/physiology , HIV-1/physiology
SELECTION OF CITATIONS
SEARCH DETAIL
...