Evaluating patient flow through an emergency ophthalmology consult service in a tertiary care academic centre in Quebec.

OBJECTIVE: This study aims to characterize the epidemiology, common reasons, and diagnostic accuracy of referrals made by emergency departments (EDs) and optometrists to an emergency ophthalmology consultation service as well as to identify opportunities for improvement. DESIGN: Retrospective chart review. PARTICIPANTS: A total of 1249 referrals made to the emergency ophthalmology consultation service at a tertiary care centre between July 2018 and June 2019. METHODS: Patient charts were examined, and clinical variables were extracted. Statistical significance (p < 0.05) was determined via t tests and χ2 tests for continuous and categorical variables, respectively. Diagnostic accuracy of providers and time delay between referral and ophthalmologic encounter also were assessed. RESULTS: Both EDs and optometrists most often referred cases with vitreoretinal (36.48% and 37.19%, respectively) and corneal pathology (21.42% and 20.25%, respectively). Optometrists (n = 240; 52.48%) were significantly more accurate in their diagnoses than EDs (n = 940; 32.45%; p < 0.00001). Specifically, optometrists were significantly more accurate when diagnosing anterior-chamber (n = 29; 58.62%; p = 0.039) and vitreoretinal (n = 89; 60.67%; p < 0.00001) pathology than EDs (anterior chamber, n = 77, 36.36%; vitreoretinal, n = 344, 18.90%). Across all ED referrals (n = 940), 58 (6.17%) had a prolonged delay. Across all optometrist-to-ED referrals (n = 150), 6 (4.00%) had a prolonged delay. Accounting for all cases, the total incidence of prolonged delay was 5.87%. CONCLUSIONS: Our results demonstrate the need for improved communication between optometrists and ophthalmologists to reduce the wait-time burden on EDs. Patients may benefit from direct referral by optometrists to ophthalmologists. Education of allied health professionals on ophthalmic disease also may improve diagnostic accuracy.

The Role of Liver Biopsy in Investigation of Cholestatic Liver Disease in Infancy.

OBJECTIVES: The objective of this study was to assess the diagnostic yield and impact on management of liver biopsy in infants with cholestatic jaundice. METHODS: A retrospective cohort study of infants with cholestasis who underwent liver biopsy before one year of age between December 2002 and December 2013 at the Montreal Children's Hospital was conducted. Biopsies were reviewed by a single pathologist. The diagnostic yield of the biopsy was assessed in terms of its role in establishing a diagnosis, excluding an important diagnosis or changing management. RESULTS: Seventy-nine biopsies were performed within the time frame outlined, with 58 fulfilling inclusion criteria. Liver biopsies were found to add novel information in 21 cases (36.2%). The diagnostic yield of the biopsy was unrelated to the severity of direct hyperbilirubinemia, age at biopsy, age at admission, co-morbidities, stool color at presentation and TPN exposure. Among infants under 90 days of age, 21 also underwent cholangiography, the results of which were consistent with biopsy findings. There were four (6.9%) documented complications from biopsies, including bleeding and accumulation of free fluid in the peri-hepatic area. CONCLUSIONS: Liver biopsy is an invasive test used with other clinical modalities to determine the etiology of neonatal cholestasis. These results suggest that biopsy added novel information to the diagnostic workup in 36.2% of cases with a complication rate of 6.9%. Consequently, the role and timing of liver biopsy need to be reassessed to determine which patients would most benefit from this procedure.

Impact of surgical case order on epiretinal membrane peeling surgery.

OBJECTIVE: To determine whether surgical warm-up affects epiretinal membrane (ERM) peeling complication rates and surgical case times. SETTING: Jewish General Hospital, Montreal, QC, Canada. DESIGN: Retrospective case-control study. METHODS: We assessed consecutive patients who underwent pars plana vitrectomy for ERM peel (macular pucker) by one surgeon at the Jewish General Hospital from January 2006 until March 2016. Cases evaluated were sequential ERM peels performed as the first 2 surgeries of the day. The first case of the day was considered the "warm-up" and the second case was the "post-warm-up." Baseline demographics, pre-operative characteristics, perioperative and postoperative best-corrected visual acuity (BCVA) at 2 months and 6 months, as well as postoperative complications are described. Results were analyzed using the χ2 test, t test, and Fischer's exact test. Regression models were used to identify any predictors of postoperative BCVA. RESULTS: The study reviewed 108 patients. The warm-up group was compared with the post-warm-up group, and there was no significant difference between the mean pre-operative BCVA and the post-operative BCVA at 2 and 6 months. ERM peeling surgery complication rates were not statistically different between the warm-up cases and the post-warm-up cases. There was a tendency for performing complex surgeries that needed phaco procedures in post-warm-up cases (13% vs 2%, p = 0.03). Analysis of simple ERM peeling procedures (with no concomitant phaco procedures) showed no statistically significant tendencies for any of the groups to go beyond the 60 minutes allocated for the surgery (25.4% vs 20.0%, p = 0.27). CONCLUSION: Warming-up does not influence the rate of postoperative complications or the postoperative BCVA in patients undergoing ERM peels. The strongest predictor of post-operative BCVA was pre-operative BCVA.

Regeneration of tissues of the oral complex: current clinical trends and research advances.

Regenerative therapy in oral health care is limited by both the body's natural capacity for regeneration and the materials and methods currently available. Research on various aspects of regenerative therapy, such as tissue engineering and stem cell and gene therapy, has produced promising results. Compelling advances, ranging from the discovery and characterization of stem cell populations in oral tissue to the engineering and transplantation of whole tooth structures, could result in exciting new treatment methods for clinicians in the near future. In this review, we discuss the limitations of natural healing and regeneration of various tissues of the oral complex, including teeth, periodontium and salivary glands, and summarize current treatment methods for tissue damage as well as research advances in oral tissue regeneration.