ABSTRACT
Cardiovascular disease (CVD) is largely preventable, and the leading cause of death for men and women. Though women have increased life expectancy compared to men, there are marked sex disparities in prevalence and risk of CVD-associated mortality and dementia. Yet, the basis for these and female-male differences is not completely understood. It is increasingly recognized that heart and brain health represent a lifetime of exposures to shared risk factors (including obesity, hyperlipidemia, diabetes, and hypertension) that compromise cerebrovascular health. We describe the process and resources for establishing a new research Center for Women's Cardiovascular and Brain Health at the University of California, Davis as a model for: (1) use of the cy pres principle for funding science to improve health; (2) transdisciplinary collaboration to leapfrog progress in a convergence science approach that acknowledges and addresses social determinants of health; and (3) training the next generation of diverse researchers. This may serve as a blueprint for future Centers in academic health institutions, as the cy pres mechanism for funding research is a unique mechanism to leverage residual legal settlement funds to catalyze the pace of scientific discovery, maximize innovation, and promote health equity in addressing society's most vexing health problems.
ABSTRACT
The first case of novel Coronavirus (COVID-19) was reported in December 2019 in Wuhan City, China and led to an international outbreak. This virus causes serious respiratory illness and affects several other organs of the body differently for different patient. Worldwide, several waves of this infection have been reported, and researchers/doctors are working hard to develop novel solutions for the COVID diagnosis. Imaging and vision-based techniques are widely explored for the prediction of COVID-19; however, COVID infection percentage estimation is under explored. In this work, we propose a novel framework for the estimation of COVID-19 infection percentage based on deep learning techniques. The proposed network utilizes the features from vision transformers and CNN (Convolutional Neural Networks), specifically EfficientNet-B7. The features of both are fused together for preparing an information-rich feature vector that contributes to a more precise estimation of infection percentage. We evaluate our model on the Per-COVID-19 dataset (Bougourzi et al., 2021b) which comprises labeled CT data of COVID-19 patients. For the evaluation of the model on this dataset, we employ the most widely-used slice-level metrics, i.e., Pearson correlation coefficient (PC), Mean absolute error (MAE), and Root mean square error (RMSE). The network outperforms the other state-of-the-art methods and achieves 0 . 9886 ± 0 . 009 , 1 . 23 ± 0 . 378 , and 3 . 12 ± 1 . 56 , PC, MAE, and RMSE, respectively, using a 5-fold cross-validation technique. In addition, the overall average difference in the actual and predicted infection percentage is observed to be < 2 % . In conclusion, the detailed experimental results reveal the robustness and efficiency of the proposed network.
ABSTRACT
BACKGROUND: Burn injuries are one of the most severe forms of wounds and trauma across the globe. Automated burn diagnosis methods are needed to provide timely treatment to the concerned patients. Artificial intelligence is playing a vital role in developing automated tools and techniques for medical problems. However, the use of advanced AI techniques for color images based burn region segmentation is not much explored. METHOD: In this work, we explore the use of deep learning for the challenging problem of burn region segmentation. We prepared a pixel-wise labelled new burn images dataset for segmentation and investigated the efficacy of existing state-of-the-art color images based semantic image segmentation techniques. Lately, we proposed a new convolution neural network (CNN) that uses atrous convolution for encoding rich contextual information and utilizes pre-trained model ResNet-101 for better extraction of low-level and middle-level layer features. RESULTS: The proposed approach achieves the state-of-the-art performance on the prepared burn image dataset with 77.6% of Mathews correlation coefficient (MCC) and 93.4% of accuracy. The improvement of 11.6/5.8/6.9/1.2% is observed in precision, Dice similarity coefficient, Jaccard index and specificity, in comparison to the second best performance. CONCLUSION: In this work, we propose a CNN based novel method for performing burn-region segmentation in color images and evaluate it using newly prepared Burn Images dataset. The experimental results illustrate its effectiveness in comparison to existing approaches. Further, the proposed pixel-level segmentation method could be useful in estimating the burn surface area and burn severity in an accurate and time efficient manner.
Subject(s)
Burns/diagnostic imaging , Image Processing, Computer-Assisted/standards , Neural Networks, Computer , Humans , Image Processing, Computer-Assisted/methods , Image Processing, Computer-Assisted/statistics & numerical data , Machine Learning/standards , Machine Learning/statistics & numerical dataABSTRACT
BACKGROUND AND OBJECTIVE: Burns are a serious health problem leading to several thousand deaths annually, and despite the growth of science and technology, automated burns diagnosis still remains a major challenge. Researchers have been exploring visual images-based automated approaches for burn diagnosis. Noting that the impact of a burn on a particular body part can be related to the skin thickness factor, we propose a deep convolutional neural network based body part-specific burns severity assessment model (BPBSAM). METHOD: Considering skin anatomy, BPBSAM estimates burn severity using body part-specific support vector machines trained with CNN features extracted from burnt body part images. Thus BPBSAM first identifies the body part of the burn images using a convolutional neural network in training of which the challenge of limited availability of burnt body part images is successfully addressed by using available larger-size datasets of non-burn images of different body parts considered (face, hand, back, and inner forearm). We prepared a rich labelled burn images datasets: BI & UBI and trained several deep learning models with existing models as pipeline for body part classification and feature extraction for severity estimation. RESULTS: The proposed novel BPBSAM method classified the severity of burn from color images of burn injury with an overall average F1 score of 77.8% and accuracy of 84.85% for the test BI dataset and 87.2% and 91.53% for the UBI dataset, respectively. For burn images body part classification, the average accuracy of around 93% is achieved, and for burn severity assessment, the proposed BPBSAM outperformed the generic method in terms of overall average accuracy by 10.61%, 4.55%, and 3.03% with pipelines ResNet50, VGG16, and VGG19, respectively. CONCLUSIONS: The main contributions of this work along with burn images labelled datasets creation is that the proposed customized body part-specific burn severity assessment model can significantly improve the performance in spite of having small burn images dataset. This highly innovative customized body part-specific approach could also be used to deal with the burn region segmentation problem. Moreover, fine tuning on pre-trained non-burn body part images network has proven to be robust and reliable.