1.
Chem Commun (Camb)
; 55(83): 12487-12490, 2019 Oct 25.
Article
in English
| MEDLINE
| ID: mdl-31566647
ABSTRACT
CF2H-Pseudoprolines obtained from difluoroacetaldehyde hemiacetal and serine are stable proline surrogates. The consequence of the incorporation of the CF2H group is an important decrease of the trans to cis amide bond isomerization energy and a remarkable stabilisation of the cis conformer by an hydrogen bond.