ABSTRACT
One hundred and eighty-five patients with Stage I cancer of the endometrium were irradiated preoperatively. All were irradiated to the whole pelvis by external beam only using supermegavoltage apparati. The total mid-pelvis dose ranged from 4500 cGy/5 weeks to 5500 cGy/6 1/2 weeks. Surgery followed usually in 6 weeks. Complications were minimal. Disease-free survival at Stage IA was 92.4% 5-year, 87.7% 10-year; Stage IB was 83.5% 5-year, 74.6% 10-year. Prognosis was related to stage, grade, depth of myometrial penetration, the presence of "residual" tumor at hysterectomy. External beam preoperative irradiation is recommended for all Stage I patients; Stage IB with higher grade pathology should have intracavitary irradiation supplemental to the external irradiation.
Subject(s)
Uterine Neoplasms/radiotherapy , Adenocarcinoma/mortality , Adenocarcinoma/radiotherapy , Adenocarcinoma/surgery , Adenocarcinoma, Papillary/mortality , Adenocarcinoma, Papillary/radiotherapy , Adenocarcinoma, Papillary/surgery , Adult , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/mortality , Carcinoma, Squamous Cell/radiotherapy , Carcinoma, Squamous Cell/surgery , Cobalt Radioisotopes/adverse effects , Cobalt Radioisotopes/therapeutic use , Combined Modality Therapy , Female , Humans , Middle Aged , Prognosis , Radioisotope Teletherapy/adverse effects , Radiotherapy, High-Energy/adverse effects , Uterine Neoplasms/mortality , Uterine Neoplasms/surgeryABSTRACT
One hundred and thirty-seven patients with TNM staged T1 glottic cancer were treated from 1966 to 1980. The patient characteristics were no different from those noted in previous studies. Patients were treated either with 60Co teletherapy units or 4 MeV linear accelerators with different daily (180-225) and weekly (4 times vs. 5 times) fractionation schemes. A recurrent-free survival was attained in 80% of the patients 2 years after primary treatment with radiation therapy. There were 27 local recurrences, of which 82% were salvaged with surgery for an overall adjusted survival of 95%. Patients treated on 60Co units with field sizes less than or equal to 30 sq. cm had a 15% increase in local recurrence compared with field size greater than 30 sq. cm, which could not be attributed to lower doses. Poorly differentiated tumors and those involving the anterior commissure were more likely to develop a local recurrence. Doses above 1900 ret were associated with a decrease in local recurrence in patients having anterior commissure involvement. Salvage with limited surgery for failure was effective in selected cases.
Subject(s)
Laryngeal Neoplasms/radiotherapy , Vocal Cords , Adult , Aged , Cobalt Radioisotopes/therapeutic use , Female , Humans , Laryngeal Neoplasms/pathology , Male , Middle Aged , Neoplasm Recurrence, Local , Particle Accelerators , Radioisotope Teletherapy , Radiotherapy, High-Energy , SmokingABSTRACT
Some effects of irradiation of rat brain with single doses of X rays or fast neutrons have been measured. This was done by estimating the total number of cells in the subependymal layer at various times after irradiation. The gross response to X rays and neutrons was somewhat different, and the results suggest that the two histologically distinguishable cell types in the subependymal layer have different values of RBE.