1.
Org Lett
; 15(2): 414-7, 2013 Jan 18.
Article
in English
| MEDLINE
| ID: mdl-23272941
ABSTRACT
The histone lysine monomethyltransferase SETD8 is an epigenetic regulator of cell cycle progression. Nahuoic acid A (1), a polyketide produced in culture by a Streptomyces sp. obtained from a tropical marine sediment, is the first known selective SAM-competitive inhibitor of SETD8. The structure of nahuoic acid A (1) has been elucidated by chemical transformation and detailed analysis of spectroscopic data.