ABSTRACT
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) is one of the common lymphoproliferative disorders with an increased risk of developing subsequent neoplasms of epithelial and mesenchymal origin. The decreased immunity and B-cell dysfunction in CLL probably accounts for this emergence of secondary malignancy. Breast, brain, skin and prostate tumors have been reported as usual coincident malignancies of CLL, while in occasional cases CLL may occur with malignancies of other solid organs, such as skin, lung, heart, and prostate. Synchronous CLL with urothelial carcinoma (UC) is an infrequent occurrence. We report this case because of its rarity in Indian literature and interesting hematological, immunophenotypic, histopathological, and cytopathological features of metastatic high-grade UC in a 61-year-old male with CLL.
Subject(s)
Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Liver Neoplasms/secondary , Neoplasms, Multiple Primary/pathology , Urinary Bladder Neoplasms/pathology , Humans , Male , Middle Aged , PrognosisABSTRACT
A 10-year-old female child, a known case of Beta-Thalassemia major with superimposed chronic Hepatitis C Viral (HCV) infection, underwent bone marrow transplantation and presented, 7 months later, with worsening hepatic functions and skin rash. Considering the wide variety of possible etiologies, she was evaluated and later confirmed as a case of hepatic dysfunction secondary to HCV related hepatic injury with concomitant chronic graft versus host disease (dermatological involvement only).
ABSTRACT
Actinomycosis is a chronic suppurative infection that can occur in the head and neck region. Though cervico-facial actinomycosis is well described, primary actinomycosis of the salivary gland is rare and can present as any other suppurative infection or can simulate malignancy. We hereby report a case of a young male with primary actinomycosis of submandibular gland, presenting as acute suppurative infection and diagnosed on histopathology.
