Subject(s)
Anti-Inflammatory Agents/administration & dosage , Antibodies, Monoclonal/administration & dosage , Crohn Disease/complications , Crohn Disease/diagnosis , Gastrointestinal Agents/administration & dosage , Melkersson-Rosenthal Syndrome/drug therapy , Melkersson-Rosenthal Syndrome/etiology , Adolescent , Crohn Disease/drug therapy , Female , Humans , Infliximab , Perfusion , Treatment OutcomeABSTRACT
Collagenous colitis belongs to the group of microscopic colitis. The aetiology and pathogenesis are unknown but different pathogenic hypothesis, autoimmune, infectious, alimentary and medicinal being are advanced, the last one being the most frequent aetiology. The collagenous gastritis is a rare entity and its association with collagenous colitis was exceptionally reported, only six cases being published. We report the seventh case of collagenous gastritis, ileitis and colitis in a 75-year-old woman with chronic diarrhea and important weight loss. This thickened subepithelial collagen band was appeared in an autoimmune injury context with antecedent of Hashimoto's thyroiditis and probably chronic atrophic Biermer's gastritis. The clinical and histological evolution was favourable with budesonide.
Subject(s)
Anti-Inflammatory Agents/therapeutic use , Autoimmune Diseases/drug therapy , Budesonide/therapeutic use , Colitis, Collagenous/drug therapy , Gastritis/drug therapy , Ileitis/drug therapy , Aged , Autoimmune Diseases/metabolism , Colitis, Collagenous/complications , Colitis, Collagenous/immunology , Collagen/metabolism , Female , Gastric Mucosa/metabolism , Gastric Mucosa/pathology , Gastritis/complications , Gastritis/immunology , Gastritis/metabolism , Hashimoto Disease/complications , Humans , Ileitis/complications , Ileitis/immunologyABSTRACT
Cytomegalovirus (CMV) infection of the gastrointestinal tract occurs mainly in immunosuppressed patients. We report here the case of a 76-Year-old woman, without obvious cause of immunosuppression, who developed severe proctitis. The clinical course was favourable with ganciclovir therapy. In the absence of controlled data in the field of CMV intestinal infections in immunocompetents, we discuss the potential benefit of an antiviral therapy in those patients who do not recover rapidly and spontaneously.
Subject(s)
Cytomegalovirus Infections/diagnosis , Proctocolitis/diagnosis , Proctocolitis/virology , Rectal Neoplasms/diagnosis , Acute Disease , Aged , Cytomegalovirus Infections/immunology , Diagnosis, Differential , Female , HumansABSTRACT
Villous atrophy of the terminal ileum is usually secondary to celiac disease or other diseases. Very few cases of primary ileal villous atrophy have been reported in the literature. We report here the case of a 37-year-old man with chronic diarrhea since childhood without features of malabsorption. The macroscopic and microscopic appearance of the duodenal, ileal and colonic mucosae at endoscopy and contrast radiography of the small bowel was normal. Ileal lesions consisted of total villous atrophy. Search for antinuclear antibodies, anti-endomysium and anti-gliadin IgA and IgG and HIV serology were negative. Serum immunoglobulin level was normal. Diarrhea resolved under treatment with colestyramine.
Subject(s)
Diarrhea/etiology , Ileum/pathology , Intestinal Mucosa/pathology , Adult , Atrophy , Chronic Disease , Humans , MaleSubject(s)
Alcoholism/complications , Antidepressive Agents, Tricyclic/adverse effects , Chemical and Drug Induced Liver Injury/etiology , Hepatitis C, Chronic/complications , Thiazepines/adverse effects , Alanine Transaminase/blood , Alkaline Phosphatase/blood , Antidepressive Agents, Tricyclic/metabolism , Aspartate Aminotransferases/blood , Biopsy, Needle , Chemical and Drug Induced Liver Injury/diagnosis , Chemical and Drug Induced Liver Injury/metabolism , Humans , Male , Middle Aged , Thiazepines/metabolism , Time FactorsSubject(s)
Cocaine/adverse effects , Pancreatitis/chemically induced , Acute Disease , Adult , Female , HumansSubject(s)
Benzoxepins/adverse effects , Colitis/chemically induced , Lymphocytes/pathology , Adult , Colitis/pathology , Female , HumansABSTRACT
Hepatocellular carcinoma is a malignant tumor with a poor prognosis, particularly when it is unresectable. The results of tamoxifen treatment in hepatocellular carcinoma have been disappointing and randomized studies have shown conflicting results. We report the case of a 72-yr-old-man with histologically confirmed hepatocellular carcinoma on a normal liver, that regressed with tamoxifen treatment. Regression was confirmed by normalization of serum alpha-fetoprotein levels and a significant decrease in radiological lesions by 66%. The patient was alive in excellent clinical condition more than 30 months after the initial diagnosis.