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Chem Commun (Camb)
; 56(24): 3543-3546, 2020 Mar 24.
Article
in English
| MEDLINE
| ID: mdl-32104853
ABSTRACT
An enantioconvergent method for the alkylation of o-disubstituted aryl ketones with racemic secondary alcohols is described. This process is mediated by a commercially available iridium catalyst and proceeds via hydrogen borrowing catalysis. The highly enantioenriched ß-substituted ketone products were readily cleaved to a wide range of functional groups via retro-Friedel-Crafts acylation.