[Transformation of secondary myelodysplastic syndrome to atypical chronic myeloid leukemia in a female patient with acute myeloid leukemia]. / Transformatsiya vtorichnogo mielodisplasticheskogo sindroma v atipichnyi khronicheskii mieloleikoz u bol'noi ostrym mieloidnym leikozom.

Secondary myeloid neoplasia may be a complication of intensive cytostatic therapy. The most common types of secondary neoplasias are acute myeloid leukemia and myelodysplastic syndrome. The development of secondary atypical chronic myeloid leukemia (aCML) is an extremely rare phenomenon. The paper describes transformation of secondary myelodysplastic syndrome to aCML 6 months after its diagnosis. The development of aCML was accompanied by additional chromosomal aberration as monosomy of chromosome 17. No mutations in the JAK2, MPL, and CalR genes were detected. It is concluded that the clinical course of secondary myeloid neoplasias is variable.

[Matrix metalloproteinase-9 in plasma of bone marrow aspirates of patients with acute myeloid leukemia and myelodysplastic syndrome].

There was studied the level of matrix metalloproteinase-9 (MMP-9) in plasma of bone marrow aspirates in 87 patients: 39 with acute myeloid leukemia (AML) and 48 myelodysplastic syndrome (MDS). It has been found out an association of the level of MMP-9 in plasma of bone marrow aspirates in patients with AML and MDS with a volume of leukemic mass.

[The influence of ezetimibe and simvaststin on platelet aggregation and protein c system in patients with coronary heart disease and hypercholesterolemia].

Therapy with ezetimib (10 mg daily for 2 weeks) caused a 24% reduction of plasma LDL cholesterol level (p < 0.05) and maximum ADP and collagen-induced platelet aggregation from 76.2 +/- 1.54 to 65.3 +/- 3.38% and from 71.5 +/- 3.98 to 53.6 +/- 5.24% (p < 0.05) respectively. Combination of ezetimibe and simvaststin did not produce an additional decrease in platelet aggregation.

[Combination of methods of preoperative reserving autoblood components in selective surgery].

Reservation of blood components, done in good time, for autotransfusion to patients being prepared for elective surgery are the method of choice in solution of the tasks of an adequate preoperative preparation of the patients. Using autogenous erythrocytes and plasma increases infective safety and effectiveness of postoperative transfusion therapy. The application of present-day methods of intensive preoperative storage of autohemocomponents and wide using them in every-day medical practice is a necessary condition of the elevation of efficiency of treatment of elective surgical patients.

[The transfusion service in the multi-type medical institution].

The importance of the transfusion maintenance of the curative process becomes so crucial that it needs the institution of specialized service. The practical experience and the analysis of the material testify the necessity of the separate transfusion service in the multi-type medical institution. Its structural and functional characteristics are discussed. Such kind of approach allows to optimize the provision of the patients with the high-quality and virus-free blood components. These measures result in the positive economic effect due to the rational use of resources, decreasing of time period of patients stay in the hospital and enhancement of therapy effectiveness.

[Effects of efferent methods of treatment on hemostasis in patients with postinfarction aneurysms of the left ventricle].

Surgical operation of coronary shunting with resection of postinfarction aneurysm of the left ventricle (PALV) had to be done on 65 patients. Automatic plasmapheresis (AP) and plasmothrombocytopheresis (PTCA) were performed in the reoperation period for transfusion maintenance. The cellular composition of peripheral blood was not changed under the influence of cellular operations with the exception of thrombocytes: after PTCA their content was reliably decreased. AP and PTCA operations in patients with PTLV led to initially increased content of blood fibrinogen, whole protein in 24 hours, but by the time of operation the indices of protein metabolism were stabilized at the initial level. The operations of AP and PTCA were followed by a reliably decreased concentration of cholesterol, beta-lipoproteins and triglycerides that was associated with plasma exfusion. PA and PTCA fulfilled before operation in PALV patients allow both reservation of autologous plasma and thrombocytes and normalization of certain indices of hemostasis.

[The hemotransfusion therapy rendered to the wounded during antiterrorist operation].

The blood transfusion therapy volume and structure at various stages of medical care in the wounded at antiterrorist operation on Northern Caucasus in 1999-2002 are discussed. The differences in the blood transfusion therapy structure at various stages of the military operation are established. In specialized medical care the use of blood components and products reached 86.2%, while in qualified medical care this rate was 78.7%. The blood transfusion therapy volume depended on the injury's type and location.

[Emergence, state-of-the-art and outlooks of the cryopreservation of blood cells in Russia].

Cryopreseration of erythrocytes at ultralow temperature combined with long-term storage of erythrocytes frozen in disposable polymer hemocontainers at moderately low temperature (-30 : -80 degrees C) inside freezers with cryopreservatives based on propyleneglycol and glycerin is now the most promising type of low-temperature blood bank in Russia.

[Storage of autologous hemocomponents in patients before endoprosthesis of great joints].

Storage of autologous hemocomponents in patients prepared for elective surgery is the method of choice for adequate preparation before surgery. Autogenic erythrocytes and blood plasma increase infectious safety and efficacy of postoperative transfusion therapy. Up-to-date storage of autologous hemocomponents is indispensable condition for effective treatment of orthopedic patients.

[Transfusiological aspects of preoperative management of patients for endoprosthesing large joints].

The preliminary preserving of blood components of patients prepared for planned operations is the method of choice in solution of the tasks of adequate preoperative management. The use of autologous erythrocytes and plasma raises the infection safety and effectiveness of postoperative transfusion therapy. Modern methods of intensive preoperative preparation of autohemocomponents and wide introduction of them into the everyday medical practice is considered to be a necessary condition for raising the efficiency of treatment of planned surgical patients.

[Characteristics of the provision of hemotransfusion materials to the wounded and patients during antiterrorist operation]. / Osobennosti obespecheniia gemotransfuzionnymi sredstvami ranenykh i bol'nykh v usloviiakh antiterroristicheskoi operatsii.

The authors analyze the experience of organization of the wounded and patient provision with hemotransfusion materials to render assistance during antiterrorist operation in Republic of Dagestan and Republic of Chechnya in 1999-2001. It is shown that supply of military treatment-and-prophylactic institutions deployed in the zone of military conflict, of specialized hospitals with hemotransfusion materials was the following: with blood preparations (at the expense of centralized deliveries), with blood components (91.8%, at the expense of centralized deliveries form the district blood transfusion station). The volume of stored blood taken from emergency reserve donors in the military treatment-and-prophylactic institutions located near the zone of military actions constituted 8.2% of the total volume of blood components received.

[Intraoperative reservation of auto-blood in surgical treatment of ischemic heart disease]. / Intraoperatsionnoe rezervirovanie autokrovi u bol'nykh pri khirurgicheskom lechenii ishemicheskoi bolezni serdtsa.

The article presents results of using the method of intraoperative autotransfusion in surgical treatment of IHD. It was shown that in patients with IHD intraoperative reservation of 400 ml of autoblood at the stage of surgical access (prior to infusion of heparin) during coronary shunting did not lead to disturbances of hemodynamics, gas exchange and oxygen-transporting function of blood. The following transfusion of predonated autoblood at the final stage of operation promotes the early reestablishment of the circulating erythron and allows to reduce the requirement of transfusion of the donor erythrocyte concentrate by 26.1%, and chilled plasma--by more than 1.5 times.

[Intravascular photohemotherapy in the complex prophylaxis of purulent-septic complications after coronary shunting]. / Vnutrisosudistaia fotogemoterapiia v kompleksnoi profilaktike gnoino-septicheskikh oslozhnenii posle koronarnogo shuntirovaniia.

The article presents results of treatment of 78 patients with the history of coronary bypass operations for ischemic heart disease. There were 48 patients with high risk factors of the development of pyo-septic complications. Among them there were 27 patients treated by complex postoperative therapy including intravascular photomodification of blood. The intravascular irradiation of blood was shown to have a positive influence upon the development of the early postoperative period in this category of patients. The immunomodulating effect was noted due to a greater amount of activated lymphocytes and T-helpers in blood. The positive dynamics of immunological indices were in correspondence with the data of the clinical state, pyo-inflammatory complications were not registered in this group of patients. Early (on the 3rd-5th days) inclusion of the intravascular irradiation of blood in the complex postoperative therapy is thought to be expedient for the patients with high risk of pyo-inflammatory complications.

[The past, present and future of the blood service of the Armed Forces]. / Proshloe, nastoiashchee i budushchee sluzby krovi vooruzhennykh sil.

Creation of the civil blood service permitted to supply the military treatment-and-prophylactic institutions with blood, to draw up the plan of support in the event of hostilities. The blood service of the USSR (Russia) Armed Forces originates from 1962 when the blood transfusion stations (BTS) were created in the military districts and navy. The departments of blood transfusion (DBT) were formed in the central hospitals and Military Medical Academy and the stations of blood storage and transfusion not in the regular staff were organized in the garrison hospitals. In 2001 the Minister of Defense of Russia approved the program "Development of RF MD blood service during the period of 2002-2006". The aim of the program is to improve the quality and to raise the effectiveness of transfusion therapy for the patients, members of servicemen' families treated in the military treatment-and-prophylactic institutions. It is necessary to intensify the control of blood and donor service, to improve its material and technical basis, to bring the material and normative basis into line with the functioning documents of the RF Ministry of Health, to train the transfusion specialists.

[Erythropoietin in the prevention and treatment of anemia in heart surgery patients]. / Eritropoétin v profilaktike i lechenii anemii u kardiokhirurgicheskikh bol'nykh.

The authors present results of using recombinant human erythropoietin in patients operated on the heart under conditions of extracorporeal blood circulation. It was found that the intravenous infusions of erythropoietin at the postoperative period accelerated the restitution of circulating erythron indices. The volume of transfusion of the donor erythrocyte-containing media to the patient is given erythropoietin was reliably less than that in the control group. The results obtained allow using erythropoietin to be recommended as an effective method of prophylactics and treatment of anemia in cardiosurgical patients.