ABSTRACT
The purpose of this study was to determine the expression of telomerase in refractory oral lichen planus. Using a polymerase chain reaction-based telomerase activity assay, we investigated telomerase activity in 20 oral lichen planus specimens (erosive 9, atrophic 11). Telomerase activity was detected in 14 cases (erosive 7, atrophic 7). Furthermore, 13 cases of lichen planus with mild dysplasia proved telomerase-positive in eight specimens and six of seven cases devoid of dysplasia were also positive in the telomerase assay. The data indicate that, in general, telomerase activity might be frequently detectable in OLP. The data also suggest that telomerase activity might not be particularly associated with the premalignant phenotype in OLP.
Subject(s)
Lichen Planus, Oral/enzymology , Mouth Mucosa/enzymology , Telomerase/metabolism , Adult , Aged , Biomarkers, Tumor/metabolism , Biopsy , Female , Humans , Lichen Planus, Oral/pathology , Male , Middle Aged , Mouth Mucosa/pathologyABSTRACT
A clinico-radiologic-histologic review of fibrous dysplasia of the jaw in ninety-one Thai patients were studied. The lesions showed a slight predilection for females and for the maxilla. The mean age of patients was about 22 years. From available radiographic findings in 11 cases, 9 cases showed radiolucent lesions with ground glass appearance and 7 out of these cases had an ill defined border. Two out of 11 cases had mixed radiolucent radiopaque lesions and one of these had a well-defined border. Histologically, approximately half of the cases showed features of metaplastic woven bone in fibrous stroma. The peak incidences of woven bone and osteoid substance were between the ages of 11 and 20 years but for lamella bone only, the incidence was increased to the age of 31 and 40 years. The stromal component of each individual case showed variable amounts of fibroblasts, collagen fibers, vascularization and giant cells.
