[A trial of the use of rulid, sumamed and makropen in the combined treatment of generalized periodontitis at a stage of exacerbation]. / Opyt primeneniia rulida, sumameda i makropena v kompleksnom lechenii generalizovannogo parodontita v stadii obostreniia.

In vitro study of the antibacterial activity of macrolide antibiotics azitromycin (sumamed), midicamycin (macropen), roxitromycin (rulide), and erythromycin demonstrated their high activity towards clinical strains of bacteroids, fusobacteria, peptostreptococci, streptococci, and corynebacteria. These antibiotics were effective in the treatment of 62 adult patients with severe and moderate generalized periodontitis. Rulide and sumamed were the most effective, macropen and erythromycin were inferior to them.

[The effect of nitazole preparations on the microflora in periodontitis]. / Vliianie preparatov nitazola na mikrofloru pri parodontite.

Twenty-three patients with generalized periodontitis were examined. Microbiologic examination of the periodontal pouch contents, making use of anaerobic cultivation, resulted in isolation and identification of 103 strains, 76 (72.8%) of which were referred to obligate anaerobes. Facultative anaerobes made up 27.2% of the total number of the isolates. Therapy with water-soluble nitasole resulted in reduction of the number of microorganisms, decrease or arrest of pus discharge from the pouch, resolution of the edema and gingival ridge hyperemia, etc. Diffusion of nitasole (water-soluble) and cliostom from various dressings used in periodontitis was studied and the efficacy of combining these dressings revealed.