[Dependence of dental status from the level of endogenous intoxication in chemical industry workers based on the oral fluid composition study]. / Zavisimost' otklonenii stomatologicheskogo statusa ot urovnia éndogennoi intoksikatsii u rabotnikov khimicheskogo proizvodstva: rezul'taty izucheniia sostava rotovoi zhidkosti.

The aim of the study was to assess the dependence of dental status from the level of endogenous intoxication in chemical industry workers. Dental examination and analysis of the composition of the oral fluid were performed in 101 workers dealing with production of chlorophenoxyherbicides (CPH) and 100 individuals of the control group having no contact with harmful production factors. The survey revealed higher intensity of dental caries among workers (RR=1.2), which is in direct correlation with the duration and degree of contact with toxicants (rxy=+1.0). It is established that the incidence, intensity and severity of periodontitis are associated with the duration and degree of contact with CPH. The study also revealed an 80% reduction in antioxidant defense in workers. The level of malonic dialdehyde (MDA) in the main group was 4 times higher (p<0.01, RR=4), while oligopeptides of average molecular weight (OAMW) - 2.2 times higher than in controls (p<0.01; RR=2.2), indicating increased lipid peroxidation and endogenous intoxication of workers of chlororganic production. MDA and OAMW levels correlated positively with the degree of involvement in chlororganic production (MDA: RR=5.6; p<0.0; OAMW: RR=3; p<0.001; rxy=+0.894) and employment duration (MDA: RR=4.4; p<0.05; rxy=+of 0.922; OAMW: RR=2.4; p<0.01). The estimation of the parameters of oral fluid is a non-invasive method for screening for occupational intoxication and the formation of risk groups.

[Status of the buccal mucosa in subjects occupationally exposed to chlorophenoxyherbicides]. / Sostoianie slizistoi obolochki rta u lits, professional'no kontaktiruiushchikh s khlorfenoksigerbitsidami.

Examinations of workers engaged in the production of chlorophenoxyherbicides showed high prevalence of diseases of the buccal and labial mucosa with a trend to development of hyperkeratosis (exfoliative cheilitis, hyperkeratosis of the tongue, lips, buccal mucosa (BM), flat form of the BM and red lip leukoplakia). Cytogenetic effects of toxins on BM result in an increase of keratinization level, higher incidence of nuclear abnormalities, and appearance of the micronuclei in BM epithelium. A direct relationship between the severity of these symptoms, duration of exposure, and intensity of workers' contact with chlorophenoxyherbicides was revealed. The complex of noninvasive and atraumatic methods used in our study helped evaluate the BM status and can be used not only for visual examination, but also for the diagnosis of transformation of the defense reaction of the epithelium into pathological process and for preclinical detection of precancer changes in BM.