Social context influences sensorimotor gating in female African cichlid fish Astatotilapia burtoni.

Disruption in prepulse inhibition (PPI), a sensorimotor gating phenomenon found in many species, has been associated with various psychiatric disorders in humans. Social defeat has been identified as a mediator of naturally evoked reductions of PPI in African cichlid fish Astatotilapia burtoni where males reversibly alter social status and their sensorimotor gating abilities. Here we investigated A. burtoni females, which establish a male-like social hierarchy with dominant (DOM) and subordinate (SUB) individuals when housed in communities without males. We asked if DOM and SUB females demonstrate socially induced PPI differences comparable to their male DOM and SUB counterparts. Results suggest that social defeat reduced PPI in SUB females as compared to DOM females (p = 0.033) and mixed-sex community female controls (p = 0.017). However, socially defeated females in same-sex communities remained proactive when engaging in antagonistic behaviors, which appears beneficial in avoiding substantial reductions in PPI as seen in reactive, socially defeated males. In open field swimming tests, SUB females exhibited increased anxiety-related behavior (thigmotaxis) as compared to females from mixed-sex communities (COM). Taken together, our results emphasize social defeat is a reliable modulator of PPI independent of sex, and anxiety related to social defeat might be a factor in mediating PPI plasticity.

[Experimental study on therapeutic effect of Dabuyin Wan on true precocious puberty in female rats].

OBJECTIVE: To study the therapeutic effect of Dabuyin Wan on true precocious puberty of female rats and its possible mechanism. METHOD: Twenty-two-day-old female SD rats were subcutaneously injected with 40 mg x kg(-1) N-methyl-DL-aspartic acid (NMA) at 14:00 and 16:00 every day; meanwhile, the rats were given Dabuyin Wan for intervention. Visual inspection was conducted for the time of vaginal opening. The first estrus was observed by yaginal smear test. Their ovaries and uterus were weighed to calculate organ coefficients. Conventional pathological slices were made to observe morphological changes in ovaries and uterus and calculate the thickness of uterine walls and the number of corpus luteums. The level of E2 in serum was detected to assess the therapeutic effect of Dabuyin Wan on NMA precocious puberty in rats. expressions of GnRH, GPR54 and Kiss-1 mRNA in hypothalamus were measured by semi-quantitative RT-PCR to investigate the possible mechanism of Dabuyin Wan. RESULT: Dabuyin Wan at 3.24 g x kg(-1) and 1.62 g x kg(-1) significantly decreased the organ coefficients in rats with precocious puberty (P < 0.05), decrease the number of vaginal openings in rats (P < 0.01) and the thickness of uterine walls and the number of corpus luteums (P < 0.05), and notably down-regulated expressions of GnRH, GPR54 and Kiss-1 mRNA in hypothalamus (P < 0.05), without significant impact on E2 in serum. CONCLUSION: Dabuyin Wan may inhibit GnRH synthesis and release as well as startup of hypothalamic-pituitary-gonadal axis by down-regulating Kiss-1/GPR54 mRNA expression in hypothalamus, in order to realize the therapeutic effect on true precocious puberty.