Individualized Statistical Modeling of Lesions in Fundus Images for Anomaly Detection.

Anomaly detection in fundus images remains challenging due to the fact that fundus images often contain diverse types of lesions with various properties in locations, sizes, shapes, and colors. Current methods achieve anomaly detection mainly through reconstructing or separating the fundus image background from a fundus image under the guidance of a set of normal fundus images. The reconstruction methods, however, ignore the constraint from lesions. The separation methods primarily model the diverse lesions with pixel-based independent and identical distributed (i.i.d.) properties, neglecting the individualized variations of different types of lesions and their structural properties. And hence, these methods may have difficulty to well distinguish lesions from fundus image backgrounds especially with the normal personalized variations (NPV). To address these challenges, we propose a patch-based non-i.i.d. mixture of Gaussian (MoG) to model diverse lesions for adapting to their statistical distribution variations in different fundus images and their patch-like structural properties. Further, we particularly introduce the weighted Schatten p-norm as the metric of low-rank decomposition for enhancing the accuracy of the learned fundus image backgrounds and reducing false-positives caused by NPV. With the individualized modeling of the diverse lesions and the background learning, fundus image backgrounds and NPV are finely learned and subsequently distinguished from diverse lesions, to ultimately improve the anomaly detection. The proposed method is evaluated on two real-world databases and one artificial database, outperforming the state-of-the-art methods.

Anomaly detection in fundus images by self-adaptive decomposition via local and color based sparse coding.

Anomaly detection in color fundus images is challenging due to the diversity of anomalies. The current studies detect anomalies from fundus images by learning their background images, however, ignoring the affluent characteristics of anomalies. In this paper, we propose a simultaneous modeling strategy in both sequential sparsity and local and color saliency property of anomalies are utilized for the multi-perspective anomaly modeling. In the meanwhile, the Schatten p-norm based metric is employed to better learn the heterogeneous background images, from where the anomalies are better discerned. Experiments and comparisons demonstrate the outperforming and effectiveness of the proposed method.

Weakly Supervised Lesion Detection From Fundus Images.

Early diagnosis and continuous monitoring of patients suffering from eye diseases have been major concerns in the computer-aided detection techniques. Detecting one or several specific types of retinal lesions has made a significant breakthrough in computer-aided screen in the past few decades. However, due to the variety of retinal lesions and complex normal anatomical structures, automatic detection of lesions with unknown and diverse types from a retina remains a challenging task. In this paper, a weakly supervised method, requiring only a series of normal and abnormal retinal images without need to specifically annotate their locations and types, is proposed for this task. Specifically, a fundus image is understood as a superposition of background, blood vessels, and background noise (lesions included for abnormal images). Background is formulated as a low-rank structure after a series of simple preprocessing steps, including spatial alignment, color normalization, and blood vessels removal. Background noise is regarded as stochastic variable and modeled through Gaussian for normal images and mixture of Gaussian for abnormal images, respectively. The proposed method encodes both the background knowledge of fundus images and the background noise into one unique model, and corporately optimizes the model using normal and abnormal images, which fully depict the low-rank subspace of the background and distinguish the lesions from the background noise in abnormal fundus images. Experimental results demonstrate that the proposed method is of fine arts accuracy and outperforms the previous related methods.