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[Expression of Oct-4 transcription factor in squamous cell skin carcinoma and seborrheic keratosis].
Nan Fang Yi Ke Da Xue Xue Bao
; 31(5): 917-8, 2011 May.
Article
in Chinese
| MEDLINE
| ID: mdl-21602158
ABSTRACT
OBJECTIVE: To detect the expression of stem cell transcription factor Oct-4 in squamous cell carcinoma (SCC) and seborrheic keratosis (SK) and its association with cancer stem cells. METHODS: Immunohistochemistry was used to detect Oct-4 expression in 35 SCC cases, 21 SK cases and 15 normal control skin tissues. RESULTS: Oct-4 expression was negative in normal skin and showed a significant difference between SCC and SK tissues (P<0.05). CONCLUSION: The Oct-4-positive cells in SCC and SK are probably tumor stem cells. Oct-4 expression may provide an important evidence for isolation and identification of human SCC and SK stem cells.