1.
Carbohydr Res
; 455: 114-118, 2018 Jan 02.
Article
in English
| MEDLINE
| ID: mdl-29207316
ABSTRACT
An efficient method for selective anomeric deacetylation of peracetylated mono-, di-, and trisaccharides has been developed by using 2 mol% Hf(OTf)4 as catalyst in acetonitrile. Employment of ultrasonic irradiation could significantly accelerate the reaction rate. Mechanistic study confirmed the hydrolysis nature of this reaction, and NMR experimental data suggested that multiple peracetylated saccharide molecules may ligate to Hf(IV) cation primarily via the anomeric acetate to promote its specific hydrolysis.
Subject(s)
Hafnium/chemistry , Oligosaccharides/chemistry , Catalysis , Molecular Structure
2.
Nucleosides Nucleotides Nucleic Acids
; 35(6): 295-304, 2016 Jun 02.
Article
in English
| MEDLINE
| ID: mdl-27104859
ABSTRACT
An efficient P(V)-N activation method for the synthesis of 5-carboxy-2'-deoxyuridine and 5-carboxy-2'-deoxycytidine triphosphates directly from the corresponding phosphoropiperidate precursors has been developed.