Spontaneous generation of singlet oxygen on microemulsion-derived manganese oxides with rich oxygen vacancies for efficient aerobic oxidation.

Developing innovative catalysts for efficiently activating O2 into singlet oxygen (1O2) is a cutting-edge field with the potential to revolutionize green chemical synthesis. Despite its potential, practical implementation remains a significant challenge. In this study, we design a series of nitrogen (N)-doped manganese oxides (Ny-MnO2, where y represents the molar amount of the N precursor used) nanocatalysts using compartmentalized-microemulsion crystallization followed by post-calcination. These nanocatalysts demonstrate the remarkable ability to directly produce 1O2 at room temperature without the external fields. By strategically incorporating defect engineering and interstitial N, the concentration of surface oxygen atoms (Os) in the vicinity of oxygen vacancy (Ov) reaches 51.1% for the N55-MnO2 nanocatalyst. This feature allows the nanocatalyst to expose a substantial number of Ov and interstitial N sites on the surface of N55-MnO2, facilitating effective chemisorption and activation of O2. Verified through electron paramagnetic resonance spectroscopy and reactive oxygen species trapping experiments, the spontaneous generation of 1O2, even in the absence of light, underscores its crucial role in aerobic oxidation. Density functional theory calculations reveal that an increased Ov content and N doping significantly reduce the adsorption energy, thereby promoting chemisorption and excitation of O2. Consequently, the optimized N55-MnO2 nanocatalyst enables room-temperature aerobic oxidation of alcohols with a yield surpassing 99%, representing a 6.7-fold activity enhancement compared to ε-MnO2 without N-doping. Furthermore, N55-MnO2 demonstrates exceptional recyclability for the aerobic oxidative conversion of benzyl alcohol over ten cycles. This study introduces an approach to spontaneously activate O2 for the green synthesis of fine chemicals.

Ultralow Doppler frequency extraction for the self-mixing dual-frequency laser velocimetry.

In self-mixing dual-frequency laser Doppler velocimetry, the self-mixing Doppler frequency shift of the optical frequency difference is a linear function of the velocity of an external dynamic object; however, it is always ultralow for signal processing. Therefore, an ultralow frequency extraction method based on artificial neural networks (NNs) is presented because NNs can accurately create a fitting function for a Doppler signal and extend the signal to the DC value, increasing the signal length and sampling points without yielding unnecessary influences on the Doppler frequency. We precisely measured Doppler frequencies in the frequency domain with a low sampling rate and calculated the velocities for a target with longitudinal movements. Compared to time-domain extraction, frequency-domain extraction can reflect the complete information of the original Doppler signal. This feature potentially contributes to the signal processing of velocimetry in practical engineering applications.

Fringe double for self-mixing interference based on the narrow transmission spectrum mapping.

In this work, a novel fringe double scheme with a Fabry-Pérot (F-P) cavity is proposed for self-mixing interferometry based on the narrow transmission spectrum mapping. While the laser beam with self-mixing interference (SMI) propagates through the F-P cavity with the narrow transmission spectrum, the SMI fringe doubles as the optical frequency modulation caused by SMI sweeps the peak of the transmission spectrum of the F-P cavity completely. The doubled SMI signal is very suitable for displacement reconstruction with fringe counting and velocity monitoring with joint time-frequency analysis, since it inherits the merits of the transmission spectrum of the F-P cavity (sharp, neat, and stable). This method has the potential to simplify signal processing and improve the resolution of SMI measurement systems.

Self-mixing birefringent dual-frequency laser Doppler velocimeter.

A self-mixing birefringent dual-frequency laser Doppler velocimeter (SBD-LDV) for high-resolution velocity measurements is presented in this paper. The velocity information of the object can be accurately extracted from the self-mixing Doppler frequency shift of the birefringent light-carried microwave signal. We generate a virtual stable light-carried microwave by using a birefringent dual-frequency He-Ne laser which further simplifies the structure of the light source. Moreover, the optical configuration based on the laser self-mixing interference brings benefits of compact optical setup, self-alignment, and direction discriminability. Experimentally, we extracted the Doppler beat frequency signal by the low-frequency (millihertz) phase lock-in amplifier, measured the beat frequency precisely in time-domain with a low sampling rate and calculated the magnitude of velocity. Compared with the previous self-mixing LDV, the average velocity resolution of SBD-LDV is improved to 0.030 mm/s for a target with longitudinal velocity, benefiting from the high stability of light-carried microwave. It is of great meaning and necessity because it helps to provide an available velocimeter with high stability and an extremely compact configuration, making a potential contribution to the velocimetry in practical engineering application.

Birefringent dual-frequency laser Doppler velocimeter using a low-frequency lock-in amplifier technique for high-resolution measurements.

A birefringent dual-frequency laser with a half-intracavity has been used to develop a laser Doppler velocimeter (LDV). The developed LDV utilizes a new signal-processing method based on a lock-in amplifier to achieve high-resolution velocity measurements and the discrimination of positive and negative velocities. Theoretical analysis and simulation results are presented. The velocity measurement experiments by using a high-precision linear stage are performed to verify the performance of the LDV. Compared with the previous dual-frequency LDVs, the average velocity resolution of the developed LDV is improved from 0.31 mm/s to 0.028 mm/s for a target without the rotational velocity. The measurement results show that our new technique can offer a powerful instrument for metrology sciences.

Curcumin protects against acetaminophen-induced apoptosis in hepatic injury.

AIM: To explore the effects of curcumin (CMN) on hepatic injury induced by acetaminophen (APAP) in vivo. METHODS: Male mice were randomly divided into three groups: group I (control) mice received the equivalent volumes of phosphate-buffered saline (PBS) intraperitoneally (ip); Group II [APAP + carboxymethylcellulose (CMC)] mice received 1% CMC (vehicle) 2 h before APAP injection; Group III (APAP + CMN) mice received curcumin (10 or 20 mg/kg, ip) 2 h before before or after APAP challenge. In Groups II and III, APAP was dissolved in pyrogen-free PBS and injected at a single dose of 300 mg/kg. CMN was dissolved in 1% CMC. Mice were sacrificed 16 h after the APAP injection to determine alanine aminotransferase (ALT) levels in serum and malondialdehyde (MDA) accumulation, superoxide dismutase (SOD) activity and hepatocyte apoptosis in liver tissues. RESULTS: Both pre- and post-treatment with curcumin resulted in a significant decrease in serum ALT compared with APAP treatment group (10 mg/kg: 801.46 ± 661.34 U/L; 20 mg/kg: 99.68 ± 86.48 U/L vs 5406.80 ± 1785.75 U/L, P < 0.001, respectively). The incidence of liver necrosis was significantly lowered in CMN treated animals. MDA contents were significantly reduced in 20 mg/kg CMN pretreatment group, but increased in APAP treated group (10.96 ± 0.87 nmol/mg protein vs 16.03 ± 2.58 nmol/mg protein, P < 0.05). The decrease of SOD activity in APAP treatment group and the increase of SOD in 20 mg/kg CMN pretreatment group were also detected (24.54 ± 4.95 U/mg protein vs 50.21 ± 1.93 U/mg protein, P < 0.05). Furthermore, CMN treatment efficiently protected against APAP-induced apoptosis via increasing Bcl-2/Bax ratio. CONCLUSION: CMN has significant therapeutic potential in both APAP-induced hepatotoxicity and other types of liver diseases.