Skin-Conformable Flexible and Stretchable Ultrasound Transducer for Wearable Imaging.

Ultrasound imaging offers a noninvasive, radiation-free method for visualizing internal tissues and organs, with deep penetration capabilities. This has established it as a crucial tool for physicians in diagnosing internal tissue pathologies and monitoring human conditions. Nonetheless, conventional ultrasound probes are often characterized by their rigidity and bulkiness. Designing a transducer that can seamlessly adapt to the contours and dynamics of soft, curved human skin presents significant technical hurdles. We present a novel flexible and stretchable ultrasound transducer (FSUT) designed for adaptability to large-curvature surfaces while preserving superior imaging quality. Central to this breakthrough is the innovative use of screen-printed silver nanowires (AgNWs) coupled with a composite elastic substrate, together ensuring robust and stable electrical and mechanical connections. Standard tensile and fatigue tests verify its durability. The mechanical, electrical, and acoustic properties of FSUTs are characterized using standard methods, with large tensile strains (≥110%), high flexibility ( R ≥ 1.4 mm), and lightweight ( ≤ 1.58 g) to meet the needs of wearable devices. Center frequency and -6-dB bandwidth are approximately 5.3 MHz and 66.47%, respectively. Images of the commercial anechoic cyst phantom yielded an axial and lateral resolution (depths of 10-70 mm) of approximately 0.31 and 0.46, and 0.34 and 0.84 mm, respectively. The complex curved surface imaging capabilities of FSUT were tested on agar-gelatin-based breast cyst phantoms under different curvatures. Finally, ultrasound images of the thyroid, brachial, and carotid arteries were also obtained from volunteer wearing FSUT.

A Novel Transformer-Based Approach for Simultaneous Recognition of Hand Movements and Force Levels in Amputees Using Flexible Ultrasound Transducers.

Accurate hand motion intention recognition is essential for the intuitive control of intelligent prosthetic hands and other human-machine interaction systems. Sonomyography, which can detect the changes in muscle morphology and structure precisely, is a promising signal source for fine hand movement recognition. However, sonomyography measured by traditional rigid ultrasound probes may suffer from poor acoustic coupling because the rigid probe surfaces cannot accommodate the curvilinear shape of the human body, particularly in the case of small and irregular residual limbs in amputees. In this study, we used a self-designed lightweight, flexible, and wearable ultrasound transducer to acquire muscle ultrasound images, and proposed a sonomyography transformer (SMGT) model for simultaneous recognition of hand movements and force levels. The performance of SMGT was systematically compared to two commonly used image processing methods, HOG and Gray Gradient, as well as a deep CNN model, in simultaneously recognizing ten classes of hand/finger movements and three force levels. Additionally, ten subjects including seven non-disabled subjects and three trans-radial amputees who are the end users of prosthetic hands were recruited to evaluate the effectiveness of SMGT. Results showed that our proposed method achieved average classification accuracies of 98.4% ± 0.6% and 96.2% ± 3.0% in non-disabled subjects and amputee subjects, respectively, which are much higher than those of other methods. This study provided a valuable approach for ultrasound-based hand motion recognition that may promote the applications of intelligent prosthetic hands.

Intravascular Optical Coherence Tomography Utilizing a Miniature Piezoelectric-Driven Probe.

Intravascular optical coherence tomography (IV-OCT) is crucial for evaluating lumen dimensions and guiding interventional procedures. However, traditional catheter-based IV-OCT faces challenges in achieving precise and full-field 360° imaging in tortuous vessels. Current IV-OCT catheters that employ proximal actuators and torque coils are susceptible to non-uniform rotational distortion (NURD) in tortuous vessels, while distal micromotor-driven catheters struggle with complete 360° imaging due to wiring artifacts. In this study, we developed a miniature optical scanning probe with an integrated piezoelectric-driven fiber optic slip ring (FOSR) to facilitate smooth navigation and precise imaging within tortuous vessels. The FOSR features a coil spring-wrapped optical lens serving as a rotor, enabling efficient 360° optical scanning. The structurally-and-functionally-integrated design significantly streamlines the probe (with a diameter of 0.85 mm and a length of 7 mm) while maintaining an excellent rotational speed of 10,000 rpm. High-precision 3D printing technology ensures accurate optical alignment of the fiber and lens inside the FOSR, with a maximum insertion loss variation of 2.67 dB during probe rotation. Finally, a vascular model demonstrated smooth probe insertion into the carotid artery, and imaging of oak leaf, metal rod phantoms, and ex vivo porcine vessels verified its capabilities for precise optical scanning, comprehensive 360° imaging, and artifact elimination. The FOSR probe exhibits small size, rapid rotation, and optical precision scanning, rendering it exceptionally promising for cutting-edge intravascular optical imaging techniques.

Flexible Ultrasound Transducer With Embedded Optical Shape Sensing Fiber for Biomedical Imaging Applications.

Flexible ultrasound transducers (FUTs), capable of conforming to irregular surfaces, have become a research hotspot in the field of medical imaging. With these transducers, high-quality ultrasound images can be obtained only if strict design criteria are fulfilled. Moreover, the relative positions of array elements must be determined, which are important for ultrasound beamforming and image reconstruction. These two major characteristics present great challenges to the design and fabrication of FUTs compared to that for traditional rigid probes. In this study, an optical shape-sensing fiber was embedded into a 128-element flexible linear array transducer to acquire the real-time relative positions of array elements to produce high-quality ultrasound images. Minimum concave and convex bend diameters of approximately 20 and 25 mm, respectively, were achieved. The transducer was flexed 2000 times, and yet no obvious damage was observed. Stable electrical and acoustic responses confirmed its mechanical integrity. The developed FUT exhibited an average center frequency of 6.35 MHz, and average -6-dB bandwidth of 69.2%. The array profile and element positions measured by the optic shape-sensing system were instantly transferred to the imaging system. Phantom experiments for both spatial resolution and contrast-to-noise ratio proved that FUTs can maintain satisfactory imaging capability despite bending to sophisticated geometries. Finally, color Doppler images and Doppler spectra of the peripheral arteries of healthy volunteers were obtained in real time.

Design and Fabrication of a High-Frequency Microconvex Array Transducer for Small Animals Imaging.

High-frequency convex array transducer, featuring both high spatial resolution and wide field of view, has been successfully developed for ophthalmic imaging. To further expand its application range to small animals' imaging, this work develops a high-frequency microconvex array transducer possessing smaller aperture size and wider scanning angle. This transducer featured 128 array elements arranged in a curvilinear 2-2 piezoelectric composite configuration, yielding a maximum view angle of 97.8°. The array was composed of two front matching layers, a nonconductive backing layer, and a customized flexible circuit that electrically connected array elements to coaxial cables. The center frequency and the -6-dB fractional bandwidth were about 18.14 MHz and 69.15%, respectively. The image of a tungsten wire phantom resulted in approximately 62.9- [Formula: see text] axial resolution and 121.3- [Formula: see text] lateral resolution. The image of the whole kidney of a rat as well as its internal arteries was acquired in vivo, demonstrating the imaging capability of the proposed high-frequency microconvex array transducers for small animals' imaging applications.

1.5-Dimensional Circular Array Transducer for In Vivo Endoscopic Ultrasonography.

OBJECTIVE: Traditional endoscopic ultrasonography (EUS), which uses one-dimensional (1-D) curvilinear or radial/circular transducers, cannot achieve dynamic elevational focusing, and the slice thickness is not sufficient. The purpose of this study was to design and fabricate a 1.5-dimensional (1.5-D) circular array transducer to achieve dynamic elevational focusing in EUS in vivo. METHODS: An 84 × 5 element 1.5-D circular array transducer was successfully developed and characterized in this study. It was fabricated with PZT-5H 1-3 composite that attained a high-electromechanical coupling factor and low-acoustic impedance. The acoustic field distribution was measured with different transmission modes to validate the 1.5-D elevational beam focusing capability. The imaging performance of the 84 × 5 element 1.5-D circular array transducer was evaluated by two wire phantoms, an agar-based cyst phantom, an ex vivo swine pancreas, and an in vivo rhesus macaque rectum based on multifocal ray-line imaging method with five-row elevational beam steering. RESULTS: It was demonstrated that the transducer exhibited a central frequency of 6.47 MHz with an average bandwidth of 50%, a two-way insertion loss of 23 dB, and crosstalk of <-26 dB around the center frequency. CONCLUSION: Dynamic elevational focusing and the enhancement of the slice thickness in EUS were obtained with a 1.5-D circular array transducer. SIGNIFICANCE: This study promotes the development of multirow and two-dimensional array EUS probes for a more precise clinical diagnosis and treatment.