Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Nat Commun ; 11(1): 4218, 2020 08 24.
Article in English | MEDLINE | ID: mdl-32839452

ABSTRACT

Exposure to social stress and dysregulated serotonergic neurotransmission have both been implicated in the etiology of psychiatric disorders. However, the serotonergic circuit involved in stress vulnerability is still unknown. Here, we explored whether a serotonergic input from the dorsal raphe (DR) to ventral tegmental area (VTA) influences vulnerability to social stress. We identified a distinct, anatomically and functionally defined serotonergic subpopulation in the DR that projects to the VTA (5-HTDR→VTA neurons). Moreover, we found that susceptibility to social stress decreased the firing activity of 5-HTDR→VTA neurons. Importantly, the bidirectional manipulation of 5-HTDR→VTA neurons could modulate susceptibility to social stress. Our findings reveal that the activity of 5-HTDR→VTA neurons may be an essential factor in determining individual levels of susceptibility to social stress and suggest that targeting specific serotonergic circuits may aid the development of therapies for the treatment of stress-related disorders.


Subject(s)
Dorsal Raphe Nucleus/physiology , Neural Pathways/physiology , Serotonergic Neurons/physiology , Stress, Psychological/physiopathology , Synaptic Transmission/physiology , Ventral Tegmental Area/physiology , Animals , Dorsal Raphe Nucleus/cytology , Dorsal Raphe Nucleus/metabolism , Glutamic Acid/metabolism , Luminescent Proteins/genetics , Luminescent Proteins/metabolism , Male , Mice, Inbred C57BL , Mice, Transgenic , Microscopy, Confocal , Serotonergic Neurons/cytology , Serotonergic Neurons/metabolism , Serotonin/metabolism , Ventral Tegmental Area/cytology , Ventral Tegmental Area/metabolism , Red Fluorescent Protein
SELECTION OF CITATIONS
SEARCH DETAIL
...