NaREP2Se6 (RE = Y, Sm, Gd-Dy): Quaternary Rare-Earth Selenophosphates with Unique 3D {[REP2Se6]-}∞ Framework Built by RESe8 and P2Se6 Motifs and Multiple Properties.

Rare-earth (RE) chalcophosphates have been widely studied because of their abundant structures. Here, five new RE selenophosphates, NaREP2Se6 (RE = Y, Sm, Gd-Dy), were synthesized by a facile RE oxide-boron-selenium solid-state route. They crystallize in the triclinic P1̅ space group, featuring three-dimensional (3D) structures constructed by RESe8 and P2Se6 motifs, different from common 2D RE chalcophosphates A-RE-P2-Q6 (A = alkali metal; Q = S, Se) system. Their structural chemistry and relationship with related phases are analyzed. Both the size of A and the coordination geometry of RE have important influences on the system's structures. Their optical band gaps are tunable from 1.79 to 2.50 eV, and they exhibit diverse magnetic behaviors, including Van-Vleck-type paramagnetism, antiferromagnetism, and ferromagnetism. Their photocurrent responses and thermal stabilities are analyzed as well. Calculation results suggest that the RESe8 and P2Se6 units make a great contribution to the optical properties. This work enriches the chemistry and multifunctional properties of RE chalcophosphates.

KREP2 Se6 (RE = Sm, Gd, Tb): The First Rare-Earth Selenophosphates with Remarkable Nonlinear Optical Activities Realized by Synergistic Effect of RE- and P-Based Motifs.

Rare-earth (RE) chalcogenides have been extensively studied as infrared nonlinear optical (NLO) materials because of their nice integrated performances; however, very few RE chalcophosphates are involved for this topic. Here, three quaternary RE selenophosphates, KSmP2 Se6 (1), KGdP2 Se6 (2), and KTbP2 Se6 (3), are profoundly studied for their NLO potentials. Their noncentrosymmetric P21 structures feature RESe8-bicapped trigonal prisms and ethane-like [P2 Se6 ]4 - dimers built {[REP2 Se6 ]-}∞ layers. As the first studied NLO-active RE selenophosphates, 1-3 exhibit second harmonic generation (SHG)responses ≈0.34-1.08 × AgGaS2 at 2.10 µm and laser-induced damage thresholds (LIDTs) ≈1.43-4.33 × AgGaS2 , and they all show phase-matchable behaviors, indicating their wonderful balanced NLO properties. Theoretical calculations demonstrate that the synergistic effect between RESe8 and P2 Se6 units makes the major contribution to the SHG responses.

Directional Growth of Conductive Metal-Organic Framework Nanoarrays along [001] on Metal Hydroxides for Aqueous Asymmetric Supercapacitors.

Metal-organic frameworks (MOFs) are promising electrochemical materials that possess large specific surface areas, high porosities, good adjustability, and high activities. However, many conventional MOFs exhibit poor conductivity, which hinders their application in electrochemistry. In recent years, conductive MOFs (cMOFs) have attracted a considerable attention. As an important transition metal hydroxide, Ni(OH)2 nanosheets exhibit a high theoretical specific capacitance and a high energy density but a poor electrical conductivity. In this study, we combined a typical cMOF(Ni-HHTP, HHTP = 2,3,6,7,10,11-hexahydroxybenzene) with Ni(OH)2 nanosheets and synthesized a series of Ni-HHTP@Ni(OH)2 nanoarrays. The composite materials exhibit a high electrical conductivity and ionic transfer efficiency and a good stability. Most importantly, our study reveals the chemical interaction between cMOFs and metal hydroxide composites and the relationship between facet exposure and the growth orientation of cMOFs. When Ni-HHTP@Ni(OH)2-2 was assembled as a positive electrode material in an aqueous asymmetric supercapacitor, 98% of the initial capacitance was maintained after 5000 cycles at a high current density of 3 A g-1. The findings of this study will provide meaningful insights into the design of cMOF composites combining other metal hydroxides.

Lactobacillus fermentum ZS40 Ameliorates Inflammation in Mice With Ulcerative Colitis Induced by Dextran Sulfate Sodium.

Ulcerative colitis is an inflammatory disease of the intestine caused by many reasons, and it may even develop into colon cancer. Probiotics are normal bacteria that exist in the human body and have been proven to regulate the balance of intestinal flora and alleviate inflammation. The current study aimed to study the effect of Lactobacillus fermentum ZS40 (ZS40) on dextran sulfate sodium (DSS)-induced ulcerative colitis mice. The length and weight of the colon were measured, and the histopathological morphological changes of colon tissue were observed to evaluate the effects of ZS40 on colitis. Biochemical kits, ELISA kits, real-time quantitative PCR (RT-qPCR), and western blot were also used to detect the effects of ZS40 on serum and colon tissue related oxidative indicators and pro-inflammatory and anti-inflammatory cytokines. We found that ZS40 could reduce colonic inflammatory cell infiltration and goblet cell necrosis, increase total superoxide dismutase and catalase in mouse serum, and reduce myeloperoxidase and malondialdehyde levels. ZS40 could down-regulate the level of proinflammatory cytokines and up-regulate the level of anti-inflammatory cytokines. More importantly, ZS40 down-regulated the relative expression of nuclear factor-κB p65 (NF-κBp65), IL-6, and TNF-α mRNA and protein, up-regulated the relative expression of inhibitor kapa B alpha (IκB-α). By regulating the NF-κB and MAPK pathways to down-regulated the relative expression of p38 and JNK1/2 mRNA and p38, p-p38, JNK1/2, and p-JNK1/2 proteins. Our study suggested that ZS40 may serve as a potential therapeutical strategy for ulcerative colitis.

Iron oxide-based nanomaterials for supercapacitors.

As highly efficient and clean electrochemical energy storage devices, supercapacitors (SCs) have drawn widespread attention as promising alternatives to batteries in recent years. Among various electrode materials, iron oxide materials have been widely studied as negative SC electrode materials due to their broad working window in negative potential, ideal theoretical specific capacitance, good redox activity, abundant availability, and eco-friendliness. However, iron oxides still suffer from the problems of low stability and poor conductivity. In this review, recent progress in iron oxide-based nanomaterials, including Fe2O3, Fe3O4, FexOy, and FeOOH, as electrode materials of SCs, is discussed. The nanostructure design and various synergistic effects of nanocomposites for improving the electrochemical performance of iron oxides are emphasized. Research on iron oxide-based symmetric/asymmetric SCs is also discussed. Future outlooks regarding iron oxides for SCs are likewise proposed.

[Clinical phenotype genotype correlation in children with hemoglobin H disease in Zhuhai area of China].

OBJECTIVE: Alpha-thalassemia is one of the most common monogene disorders in the world. Most frequently, it is caused by deletions of alpha-globin gene (-alpha or --), and less commonly resulted from the non-deletional mutation (alpha(T)alpha). Hemoglobin H (HbH) disease is the most severe type among survivors of alpha-thalassemia. The clinical presentation of children with the disease was highly heterogeneous. The aim of this study was to investigate the effect of alpha-globin genotypes in the children with HbH disease on predicting the phenotypic severity and to define the factors involved in the disease progress. METHODS: Forty-three children with the disease in Zhuhai area of Guangdong, China were examined by using established techniques to detect genotypes of alpha-globin and to determine all hematological parameters. All detailed clinical data of the cases were recorded. Then clinical and hematological findings, and the correlation with genotypes were evaluated. RESULTS: Six alpha-thalassemia mutations were detected and interacted to produce 5 HbH disease genotypes. Of these genotypes, -alpha(3.7)/--(SEA)(60%), -alpha(4.2)/--(SEA) (19%) and alpha(CS)alpha/--(SEA) (12%) HbH diseases were prevalent in the area. Compared with -alpha(3.7)/--(SEA) HbH disease, significantly lower red blood cell (RBC) count, hemoglobin (Hb), mean corpuscular hemoglobin (MCHC) and HbA(2) (P < 0.05, 0.01, 0.01 and 0.01, respectively), and significantly higher mean corpuscular hemoglobin volume (MCV) and HbH levels (both P < 0.01), and more severe clinical phenotypes were found in the HbH disease with alpha(T)alpha/--(SEA) genotype. While the differences were much more significant when compared with -alpha(3.7)/--(SEA) then compared with -alpha(4.2)/--(SEA) not only in the hematological parameters, but also in the severity of clinical phenotypes. In addition, HbH levels showed anegatively correlation with the RBC count (r = -0.39, P < 0.01). CONCLUSION: The phenotypes of HbH disease may be mainly related to the underlying genotypes. The children with alpha(T)alpha/--(SEA) genotype presented with more severe hematological and clinical phenotypes followed by the -alpha(4.2)/--(SEA) and then -alpha(3.7)/--(SEA) genotypes. But phenotypic severity was not simply related to the degree of alpha-globin deficiency. HbH levels were found to exacerbate anemia. These data might provide comprehensive and very valuable and basic information for the management of HbH disease, genetic counseling and prenatal diagnosis.