1.
Journal of Shanghai Jiaotong University(Medical Science)
; (12): 361-362, 2018.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-695671
ABSTRACT
Wdpcp,a planar cell polarity (PCP) effector gene,plays essential roles in organogenesis during embryonic development through regulating collective cell movement and ciliogenesis.WDPCP mutations are associated with Bardet-Biedl syndrome and Meckel-Gruber syndrome in human.This study revealed a novel role of Wdpcp in regulating coronary artery development in mouse,demonstrating a new pathogenic phenotype associated with mutations of this gene in human.Results of this study may help us to understand the etiology of coronary artery disease.