ABSTRACT
This paper reports on a study on improving the health and fitness of office workers in Iran using a comprehensive model. The research design was a randomized controlled trial involving 294 employees. The intervention was a 6-month program to promote physical activity. The primary outcome measure was their scores on the physical activity (PA) index recorded at 3 and 6 months. A statistically significantly increase in PA was found in the intervention group over the control group. In addition, the mean values of related health and physiological indices of the intervention group demonstrated a statistically significant increase compared to the control group. The conclusions of this study support research findings in multiple countries, that the physical activity and health of office workers can be improved in a short period.
Subject(s)
Exercise , Health Promotion , Humans , Iran , Exercise/physiology , Physical FitnessABSTRACT
Dengue fever is a dangerous infectious endemic disease that affects over 100 nations worldwide, from Africa to the Western Pacific, and is caused by the dengue virus, which is transmitted to humans by an insect bite of Aedes aegypti. Millions of citizens have died as a result of dengue fever and dengue hemorrhagic fever across the globe. Envelope (E), serine protease (NS3), RNA-directed RNA polymerase (NS5), and non-structural protein 1 (NS1) are mostly required for cell proliferation and survival. Some of the diterpenoids and their derivatives produced by nature possess anti-dengue viral properties. The goal of the computational study was to scrutinize the effectiveness of diterpenoids and their derivatives against dengue viral proteins through in silico study. Methods: molecular docking was performed to analyze the binding affinity of compounds against four viral proteins: the envelope (E) protein, the NS1 protein, the NS3 protein, and the NS5 protein. Results: among the selected drug candidates, triptolide, stevioside, alepterolic acid, sphaeropsidin A, methyl dodovisate A, andrographolide, caesalacetal, and pyrimethamine have demonstrated moderate to good binding affinities (-8.0 to -9.4 kcal/mol) toward the selected proteins: E protein, NS3, NS5, and NS1 whereas pyrimethamine exerts -7.5, -6.3, -7.8, and -6.6 kcal/mol with viral proteins, respectively. Interestingly, the binding affinities of these lead compounds were better than those of an FDA-approved anti-viral medication (pyrimethamine), which is underused in dengue fever. Conclusion: we can conclude that diterpenoids can be considered as a possible anti-dengue medication option. However, in vivo investigation is recommended to back up the conclusions of this study.
Subject(s)
Antiviral Agents/pharmacology , Dengue Virus/drug effects , Diterpenes/pharmacology , Antiviral Agents/chemistry , Antiviral Agents/pharmacokinetics , Binding Sites , Computer Simulation , Dengue/drug therapy , Dengue/virology , Diterpenes/chemistry , Diterpenes/pharmacokinetics , Drug Design , Humans , Molecular Docking Simulation , Phytochemicals/chemistry , Phytochemicals/pharmacokinetics , Phytochemicals/pharmacology , Protein Binding , RNA Helicases/chemistry , RNA Helicases/drug effects , RNA Helicases/metabolism , Serine Endopeptidases/chemistry , Serine Endopeptidases/drug effects , Serine Endopeptidases/metabolism , Viral Envelope Proteins/chemistry , Viral Envelope Proteins/drug effects , Viral Envelope Proteins/metabolism , Viral Nonstructural Proteins/chemistry , Viral Nonstructural Proteins/drug effects , Viral Nonstructural Proteins/metabolismABSTRACT
INTRODUCTION: The most prominent causes of coma are traumatic brain injuries (TBIs), which have high incidence. However, little research about the caring aspects of these patients has been done, and the notion of caring experiences is unknown. Therefore, this study was conducted to describe the care-taking experiences of coma patients and their families during and after treatment. METHODS: This study is a qualitative content analysis. Participants in this study were improved TBI patients and their families. Participants were selected purposefully. The method of data collection was 16 interviews that were held with 14 of the participants. Data were analyzed using Elo and Kyngäs conventional content analysis guidelines with MAXQDA software, version 10. RESULTS: The results showed four main themes and eight categories. Themes included "crisis," "comprehensive support," communication," and "unprofessional care." CONCLUSION: Patients and families experience a crisis during hospitalization and after discharge. Therefore, patients and families need psychological support. Informing families and communication decrease the conflicts between healthcare personnel and the family. Medical staff must be careful about their statements and behaviors during comatose patients' care because they understand the care process.
ABSTRACT
The purposes of this paper are to identify and explore ways to overcome barriers to the implementation of Watson's human caring science in Iran. A literature search was done of PubMed, Elsevier, Science Direct, Ovid, ProQuest, Web of science, and Google Scholar between 1991 and 2018 using the search terms Watson's theory, clinical nursing, nursing theory, barriers to using theory, and carative factors or processes, separately and in combination. Organizational-level, practitioner-level, and educational barriers were found, and solutions for each are explored.
