Ventral hernia mesh tack causes liver hemorrhage.

INTRODUCTION: The laparoscopic approach is an increasingly popular option for ventral hernia repair. In the wake of this new technology, unexpected complications have been reported. CASE PRESENTATION: We present the case of a patient who developed a liver laceration and hemorrhage after a mesh tacking device partially dislodged subsequent to ventral hernia repair. The patient underwent exploratory laparotomy, liver hemostasis and removal of the offending tack. DISCUSSION: Our patient partially dislodged a mesh tacking device likely after violent coughing during a bout of pneumonia. The exposed blade caused a liver laceration and hemorrhage. Few other unexpected complications of the use of mesh tacking devices have been noted in the literature. Tackless hernia repair has also been described. CONCLUSION: Laparoscopic ventral hernia repair with tacks may have unexpected complications of which the surgeon should be aware and advise patients. Our patient developed a liver laceration and symptomatic hemorrhage after partially dislodging a hernia mesh tack. Further research into tackless hernia repair may be beneficial. A low long-term recurrence rate would demonstrate if tackless hernia repair is a viable option.

Missed injuries in pediatric trauma.

Missed injuries in trauma continue to be a nemesis to the trauma surgeon. Missed injuries in adult trauma patients range in frequency from 9 to 28 per cent, with some being life threatening or permanently disabling. We report the incidence of missed injuries in pediatric trauma to be 20 per cent, in our retrospective review of 107 severe pediatric trauma patients. These missed injuries, however, were neither life threatening nor permanently disabling. We also found that mechanism of injury and patient age affected the incidence of missed injuries in our population.

The effect of peritoneal contamination on wound strength of small bowel and colonic anastomoses.

Primary bowel repair in the face of peritoneal soilage is still a controversial area. Previous studies using the rat model have demonstrated a difference in new collagen synthesis after 24 hours of peritoneal contamination. Currently, the effect of short-term fecal contamination of the peritoneal cavity on anastomotic healing and strength is not known. This study was designed to evaluate anastomotic wound strength in the face of fecal contamination during this time period. Twenty Sprague Dawley rats were randomized into two groups: twelve-hour control (n = 10) and 12-hour cecal ligation and puncture (CLP; n = 10). Both groups underwent laparotomy with either CLP (12-hour) or cecal manipulation (12-hour control). Animals were allowed to recover for 12 hours, according to their assigned groups. A second laparotomy was subsequently performed in which the CLP groups had partial cecectomy to remove the source of contamination, followed by mid-jejunal and colonic division with associated primary anastomosis. Control groups had a similar procedure without partial cecectomy. All abdomens were irrigated, and all animals received immediate postoperative antibiotics and an initial fluid bolus. Animals were recovered and received 3 days of postoperative antibiotics. On postoperative day 4, animals were sacrificed and anastomotic sites were resected. Specimens were then placed in a tensiometer and disrupted under dynamic stress. Peak load was recorded for each, and maximum standard load was calculated. Hydroxyproline content of each segment was also determined after disruption. CLP values were compared with control values using unpaired Student's t test. Statistical significance threshold was P < 0.5. There was no significant difference in maximum anastomotic wound strength or hydroxyproline content between 12-hour CLP and 12-hour control group for both small bowel and colon anastomoses. Short-term peritoneal soilage (12-hour) does not significantly effect the maximum tensile strength or hydroxyproline content of primary small bowel or colonic anastomoses in this model. This study suggests that short-term fecal contamination of the peritoneal cavity may not be a contraindication to primary bowel anastomosis.

Continuous dose furosemide as a therapeutic approach to acute respiratory distress syndrome (ARDS).

BACKGROUND: Acute respiratory distress syndrome (ARDS) is seen in a variety of clinical settings in critically ill patients. ARDS has been defined as a clinical syndrome characterized by progressive hypoxemia, tachypnea, and generalized patchy bilateral pulmonary infiltrates in the absence of cardiac failure. Furosemide has been shown to improve pulmonary gas exchange and intrapulmonary shunt in animal models of ARDS by preferential perfusion of nonedematous lung units. We hypothesized that continuous dose furosemide would improve lung injury during resuscitation from oleic acid-induced lung injury in canines. METHODS: Ten mongrel dogs were anesthetized and given intravenous oleic acid (0.1 mg/kg) to induce lung injury. Once lung injury was established (2 h) the control animals (n = 6) were continued on standard supportive therapy, and the study animals (n = 4) were started on continuous dose furosemide at 0.2 mg/kg/h. Cardiac filling pressures were maintained in all animals by infusion of isotonic saline solution. Data collected included lung injury score (LIS), cardiac index (CI), stroke volume index (SVI), pulmonary capillary wedge pressure (PCWP), urine output (UO), volume of resuscitation (VR), and pulmonary shunt fraction (Qs/Qt). Data were collected at baseline, established lung injury (2 h), and end of protocol (6 h). Data were compared between groups at various stages of the model using one-way analysis of variance with repeated measures. RESULTS: All 10 animals survived the protocol. There was no difference between the experimental and control groups at baseline or established lung injury (2 h) for CI, SVI, PCWP, or VR. There was a significant improvement in PO2/FIO2 and reduction of PEEP values in the furosemide group. There was also a statistically significant difference between experimental and control groups in LIS, Qs/Qt, and urine volumes. CONCLUSIONS: Continuous dose furosemide therapy improves LIS, PO2/FIO2, and Qs/Qt and decreases PEEP requirements in this oleic acid model of ARDS.

An evaluation of the effects of semirigid cervical collars in patients with severe closed head injury.

The use of a semirigid cervical collar has been recommended to prevent further cervical spine injury in the management of trauma patients. These cervical collars are kept on obtunded patients for prolonged periods. We assessed the incidence of cervical collar related decubiti in patients with severe closed head injury (SCHI). We also assessed the utility of fluoroscopy in clearing the cervical spine of patients with SCHI. A retrospective chart review was performed on 52 consecutive patients with SCHI at a community hospital-based Level II trauma center over an 8-month period. Thirteen of 34 patients (38%) who survived >24 hours after admission developed decubiti related to the cervical collar. The patients who developed decubiti had a significantly greater duration of cervical collar placement (21.15 +/- 0.99 days) as compared with patients who did not develop decubiti (4.42 +/- 0.79 days; P = 0.001). Eight patients had their cervical spine assessed for ligamentous injury by bedside fluoroscopy. All eight patients had early collar removal; none of these patients developed decubiti. Patients with SCHI with semirigid cervical collars kept in place for prolonged periods of time are at risk for developing decubiti. Fluoroscopy in addition to standard radiographs may "clear" the cervical spine and allow early removal of these collars.

Assessment of ventilation during the performance of a percutaneous dilatational tracheostomy: hypoventilation is not a common complication.

Percutaneous dilatational tracheostomy (PDT) is becoming an accepted cost-effective alternative to surgical tracheostomy. PDT is performed by progressive dilatation of a tracheal opening placed under bronchoscopic guidance. Case reports of hypoventilation with associated hypercarbia during the performance of PDT have raised concerns about the utility of this procedure in patients in whom hypercarbia is problematic (e.g., patients with closed head injury). In a prospective cohort analysis of 11 critically ill patients, we evaluated the effect of PDT on ventilation during and after the procedure using end tidal capnography. We found that hypercarbia does not occur during or after the performance of PDT as compared to baseline levels.

Utility of a bedside Doppler in tracking left ventricular dysfunction related to hemorrhagic shock.

Treatment of hemorrhagic shock with fluid resuscitation alone results in diastolic dysfunction as measured by peak systolic pressure/end systolic volume ratio (PSP/ESV). The purpose of this study was to test the ability of a simple Doppler device to track diastolic dysfunction in hemorrhagic shock. In this prospective, controlled crossover study, five adult swine were resuscitated from hemorrhagic shock using fluids. Diastolic dysfunction was confirmed using PSP/ESV ratio. The effect of nitroprusside and dobutamine on this diastolic dysfunction was evaluated. Data (PSP/ESV, Doppler-derived acceleration, and oxygen transport parameters) were collected at each stage of the model. Arterial pressure and oxygen transport parameters corrected to baseline values; however, the PSP/ESV and Doppler-derived acceleration failed to correct with fluid resuscitation alone. Treatment with nitroprusside and dobutamine increased oxygen transport parameters, PSP/ESV ratio, and Doppler-derived acceleration significantly. Doppler-derived acceleration tracks left ventricular dysfunction seen in hemorrhagic shock.

Changes in oxygenation and compliance as related to body position in acute lung injury.

Body positioning during mechanical ventilation for acute lung injury has not been studied in a detailed manner. We evaluated the relationship between oxygenation, compliance, and body position during mechanical ventilation of patients with acute lung injury (ALI). Sixteen patients on mechanical ventilation with a diagnosis of ALI (partial pressure of oxygen/fraction of inspired oxygen <300 and no clinical evidence of congestive heart failure) were prospectively studied. Each patient was placed in a supine position followed by a 30 degrees head elevation and a 45 degrees head elevation. Data obtained in each position (after a 45-60 minute equilibration time) included static pulmonary compliance and partial pressure of oxygen from arterial blood gas sampling. Oxygenation is not improved and compliance is adversely affected by upright body positioning as compared to the supine position in patients receiving mechanical ventilation for ALI.

Jejunal feeding in the absence of reflux increases nasogastric output in critically ill trauma patients.

Nasojejunal feeding of trauma patients is becoming a common practice. Aspiration rate comparisons between jejunal versus gastric-fed patients have been shown to be equal. We performed a retrospective evaluation of gastric output in 51 trauma patients who tolerated initiation and advancement of nasojejunal feedings. Gastric output was measured in the absence of reflux of feeds. Gastric output was compared over a 24-hour interval before initiation of feeds and after advancement to nutritionally complete levels. The increase in gastric output was found to be significant [301.9 +/- 19.8 mL/day before feeds, 587.8 +/- 47.1 mL/day (P = 0.01) after advancement of feeds]. The overall documented pulmonary aspiration rate in these patients was 5.9 per cent. Because of this significant increase in gastric output, nasogastric residual check should be performed routinely in patients receiving nasojejunal feeding.

Comparison of nonbronchoscopic techniques with bronchoscopic brushing in the diagnosis of ventilator-associated pneumonia.

OBJECTIVE: To determine the diagnostic accuracy of quantitative cultures obtained via nonbronchoscopic protected specimen brushing (PSB) and nonbronchoscopic bronchoalveolar lavage (BAL) compared with quantitative cultures obtained by bronchoscopic PSB in surgical patients suspected of ventilator-associated pneumonia. DESIGN: Prospective, crossover controlled study of 15 ventilated surgical intensive care unit patients in a university teaching hospital. METHODS: Fifteen consecutive ventilated patients suspected of ventilator-associated pneumonia on the basis of leukocytosis, purulent sputum, and appearance of chest roentgenogram were enrolled. All patients underwent nonbronchoscopic PSB and BAL followed by bronchoscopic PSB. The duration of each procedure was noted. Culture results were considered positive only if greater than 10(4) colony forming units (CFU) per milliliter were present. MAIN RESULTS: Perfect concordance was noted between bronchoscopic PSB and nonbronchoscopic BAL (kappa = 1.0). The concordance between bronchoscopic PSB and nonbronchoscopic PSB was 93% ((kappa = 0.86). The nonbronchoscopic procedures were performed in significantly less time than the bronchoscopic procedure. CONCLUSION: Nonbronchoscopic PSB and BAL provide similar microbiologic data to bronchoscopic PSB in the diagnosis of ventilator-associated pneumonia while shortening procedure time significantly.

The effect of severe closed head injury on the incidence of nosocomial infections.

Severe closed head injury is a common problem seen with trauma patients. These patients often develop infections that seem unrelated to their injury. This article describes our experiences evaluating the contribution of head injury to infection rates as compared to severe trauma without head injury. We conclude that infection rates in patients with severe closed head injury are equivalent to similarly injured patients without head injury.

Rectal pH measurement in tracking cardiac performance in a hemorrhagic shock model.

OBJECTIVE AND DESIGN: We evaluated the utility of rectal mucosal pH measurement for tracking cardiac performance in hemorrhagic shock as compared with gastric tonometry. MATERIALS AND METHODS: Hemorrhagic shock was induced in five adult swine to a mean arterial pressure of 45-65 mm Hg. Hypotension was maintained for 30 minutes, resuscitation was accomplished with the shed blood and lactated Ringer's solution (3x blood volume). Gastric tonometry, rectal pH, and oxygen transport data were obtained at baseline, 0, and 30 minutes after onset of hypotension and after resuscitation. RESULTS: Intramucosal pH readings from gastric tonometry and rectal mucosal pH both showed a significant change from baseline to 0 and 30 minutes after onset of hypotension. Data after resuscitation were found to be statistically the same as baseline values. CONCLUSIONS: Rectal mucosal pH tracks cardiac performance as well as does gastric tonometry in hemorrhagic shock without as many limitations.

Are routine blood cultures effective in the evaluation of patients clinically diagnosed to have nosocomial pneumonia?

Blood cultures are a routine part of the evaluation of patients with clinically diagnosed nosocomial pneumonia; however, their utility has not been proven. We performed a retrospective chart review of 77 consecutive trauma patients diagnosed clinically to have nosocomial pneumonia at our level 1 trauma intensive care unit. Routine blood cultures did not alter the therapy of patients clinically diagnosed to have nosocomial pneumonia. We found the incidence of gram negative pneumonia was 71.4 per cent (55/77 patients) and gram positive pneumonia was 40.3 per cent (31/77 patients). Routine blood cultures taken at the time of diagnosis of nosocomial pneumonia fail to alter therapy.

Bedside placement of polyglycolic acid mesh: a novel treatment of uncomplicated abdominal wound dehiscence.

Uncomplicated abdominal wound dehiscence is a common problem in critically ill patients undergoing general surgical procedures. In the past, a majority of these patients have been subjected to an emergency return to the operating room for wound closure to prevent evisceration. In this article, we present two successful cases of a novel bedside approach using local anesthesia and polyglycolic acid mesh in uncomplicated abdominal dehiscence to prevent evisceration.

Load-independent left ventricular function in a hemorrhagic shock model.

Load-independent left ventricular (LV) function has been recently shown to be reversibly depressed in septic shock. The peak systolic pressure to end systolic volume ratio (PSP/ESV) is a load independent measure of LV function. We evaluated PSP/ESV in a porcine model of hemorrhagic shock. Hemorrhagic shock was induced in five adult swine by arterial bleeding to a mean arterial pressure of 45-65 mmHg. This hypotension was maintained for 30 min, and then each animal was resuscitated to baseline mean arterial pressure using shed blood and crystalloid solution. Data (echocardiographically derived ejection fraction and oxygen transport parameters) were collected at baseline, after 30 min of hypotension and postresuscitation. Although the cardiac index, a marker for systolic function, and the mean arterial pressure, as well as oxygen delivery and consumption returned to baseline levels, the PSP/ESV ratio remained low despite adequate fluid resuscitation. This model provides a reproducible hemodynamically stable cardiac dysfunction associated with hemorrhagic shock.

Correlation of Doppler derived velocity change with cardiac index.

Doppler ultrasound may be used as a screen to determine the need for placement of a pulmonary artery catheter. We tested the utility of Doppler derived acceleration, in correlation with pulmonary artery catheter derived cardiac index, as a screen for pulmonary artery catheter placement in 40 trauma patients. We found the expected quadratic relationship between acceleration and cardiac index. We also found that acceleration less than 200 cm/s2 correlates well with cardiac index less than 3.0 liter/min/m2.

Recurrent amiodarone pulmonary toxicity.

Amiodarone, a widely used antiarrhythmic drug, is associated with pulmonary toxicity, with an estimated mortality of 1% to 33%. Standard treatment for amiodarone pulmonary toxicity (APT) has been discontinuance of the drug and steroid therapy. We report a case of APT that recurred after withdrawal of steroids and failed to respond to reinstatement of steroid therapy. Recurrent APT is a rare clinical entity that has been reported only twice in recent literature.

Perforated jejunal diverticula: an analysis of reported cases.

We recently encountered two cases of perforated jejunal diverticula. We analyzed the data from all available cases of perforated jejunal diverticula, including our two cases. Our purpose was to increase awareness of this rare clinical entity as a cause of abdominal pain. An extensive literature review using Medline from its inception in 1972, and a manual review of all previously published reports was performed. Data collected included age, gender, length of symptoms from history and physical exam, operative findings, type of operation, and outcome (survival). Data analysis was performed using student's t test and multivariate analysis. Survival was not influenced by gender or type of operation. When the reports documented the number of diverticula present in the area of perforation (22 cases) a majority (19/22) had multiple diverticula. Perforated jejunal diverticula are a rare clinical entity in which age, type of operation, and gender does not influence outcome, but a longer duration of symptoms before operation trended towards a worse outcome. This clinical diagnosis should be entertained as part of any evaluation of abdominal pain.

Percutaneous dilatational tracheostomy: an alternative approach to surgical tracheostomy.

Percutaneous dilatational tracheostomy (PDT) offers a nonoperative alternative to patients needing an elective tracheostomy. The technique associated with PDT is essentially a progressive dilatation using blunt-tipped dilators for the placement of a tracheostomy tube. We retrospectively compared patient charges and operating time for 18 PDTs and 18 surgical tracheostomies. Our analysis suggests that percutaneous dilatational tracheostomy is a cost-effective alternative to the open procedure for elective tracheostomy.

The effect of granulocyte colony stimulating factor in patients with leukopenia due to sepsis.

The use of granulocyte stimulating factor (G-CSF) (Neupogen, Amgen Inc., Thousand Oaks, Calif.) has become acceptable for treating both primary and acquired leukopenia. Leukopenia associated with infection is an ominous sign of overwhelming sepsis. In this article, we present two cases of infection that were related to leukopenia which were successfully treated with G-CSF.