ABSTRACT
Four new compounds, randainins A-D (1-4), were isolated from the leaves and twigs of Callicarpa randaiensis, which is an endemic species in Taiwan. Compounds 1 and 2 are diterpenoids with an unusual trans-7/5 ring system, whereas compounds 3 and 4 are diterpenoids possessing a trans-5/7 ring scaffold. The structures of the new compounds were established based on NMR and MS data analyses. Anti-inflammatory activities and cytotoxicity were tested and evaluated for these compounds. Compound 4 exhibited moderate inhibition of superoxide-anion generation with an IC50 value of 21.5 ± 2.5 µM.
Subject(s)
Callicarpa/chemistry , Diterpenes/chemistry , Anti-Inflammatory Agents/pharmacology , Crystallography, X-Ray , Diterpenes/isolation & purification , Diterpenes/pharmacology , Drug Screening Assays, Antitumor , Inhibitory Concentration 50 , Molecular Structure , Neutrophils/enzymology , Nuclear Magnetic Resonance, Biomolecular , Pancreatic Elastase/analysis , Plant Leaves/chemistry , Plant Stems/chemistry , TaiwanABSTRACT
Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1-7, in addition to the known metabolites 8-23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a CC bond between cuparenol and tetralin. The isolated new compounds were evaluated for their anti-HSV-1 and anti-inflammatory activities. The results revealed that compound 4 exhibited anti-HSV-1 activity, while compound 6 showed a significant anti-inflammatory activity.