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Clin Neuropharmacol ; 27(5): 216-8, 2004.
Article in English | MEDLINE | ID: mdl-15602101

ABSTRACT

Catatonia as a clozapine withdrawal syndrome has not been well documented. There is only 1 case of excited catatonia described with the diagnosis made according to strict criteria. The authors report a patient who developed a catatonic stuporous state following abrupt discontinuation of clozapine, associated with features of cholinergic and serotonergic hyperactivity. The catatonic state resolved within 1 week with reinstatement of clozapine. It is suggested that serotonergic hyperactivity was involved, contributed by cholinergic rebound, in the pathogenesis of this patient's clozapine withdrawal catatonic syndrome.


Subject(s)
Antipsychotic Agents/adverse effects , Catatonia/psychology , Clozapine/adverse effects , Hyperkinesis/psychology , Parasympathetic Nervous System/physiopathology , Serotonin/physiology , Substance Withdrawal Syndrome/psychology , Catatonia/etiology , Humans , Hyperkinesis/etiology , Male , Middle Aged , Recurrence , Schizophrenia/complications , Schizophrenia/drug therapy
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