Analyzing the audio signals of degenerative arthritis with an electronic stethoscope.

The advance of modern medical technology has extended people's life and increased the average age of the society. Some chronic diseases are due to the aging of the population and knee joint aging is a common disease in the elderly. Common joint pathology contains degenerative arthritis, arthroncus of knees, and gouty arthritis. Knee joints are the largest and the most complicated joints in a human body as well as the joint bearing huge pressure. Wrong posture, overuse, or vigorous exercise often cause injuries to knee joints, and such injuries could easily result in joint pathology and patients falling and breaking bones due to pain and powerlessness. An acoustic wave technology, aiming at knee joints, is designed to examine a patient's current condition of joints. An electronic stethoscope or high-resolution recording equipment is utilized for collecting necessary signals, through which the wide-frequency audio signals of knee joints could be measured for the analyses and statistics in a back-end computer. Besides, it could classify the groups with healthy and degenerative knee joints to assist physicians in proceeding non-invasive joint degeneration examination clinically and doing the most suitable rehabilitation therapy.

Preexisting antibody response against 2009 pandemic influenza H1N1 viruses in the Taiwanese population.

A novel pandemic influenza H1N1 (pH1N1) virus spread rapidly across the world in 2009. Due to the important role of antibody-mediated immunity in protection against influenza infection, we used an enzyme-linked immunosorbent assay-based microneutralization test to investigate cross-reactive neutralizing antibodies against the 2009 pH1N1 virus in 229 stored sera from donors born between 1917 and 2008 in Taiwan. The peak of cumulative geometric mean titers occurred in donors more than 90 years old and declined sharply with decreasing age. Sixteen of 27 subjects (59%) more than 80 years old had cross-reactive antibody titers of 160 or more against the 2009 pH1N1 virus, whereas none of the donors from age 9 to 49 had an antibody titer of 160 or more. Interestingly, 2 of 51 children (4%) from 6 months to 9 years old had an antibody titer of 40. We further tested the antibody responses in 9 of the 51 pediatric sera to three endemic seasonal influenza viruses isolated in 2006 and 2008 in Taiwan, and the results showed that only the 2 sera from children with antibody responses to the 2009 pH1N1 virus had high titers of neutralizing antibody against recent seasonal influenza virus strains. Our study shows the presence of some level of cross-reactive antibody in Taiwanese persons 50 years old or older, and the elderly subjects who may already have been exposed to the 1918 virus had high titers of neutralizing antibody to the 2009 pH1N1 virus. Our data also indicate that natural infection with the Taiwan 2006 and 2008 seasonal H1N1 viruses may induce a cross-reactive antibody response to the 2009 pH1N1 virus.