Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
Add more filters










Database
Language
Publication year range
1.
Small Methods ; 7(9): e2300347, 2023 09.
Article in English | MEDLINE | ID: mdl-37259275

ABSTRACT

Immunogenic cell death (ICD), a dying state of the cells, encompasses the changes in the conformations of cell surface and the release of damage-associated molecular patterns, which could initiate an adaptive immune response by stimulating the dendritic cells to present antigens to T cells. Advancements in biomaterials, nanomedicine, and micro- and nano-technologies have facilitated the development of effective ICD inducers, but the potential toxicity of these vesicles encountered in drug delivery via intravenous administration hampers their further application. As alternatives, the local drug delivery systems have gained emerging attention due to their ability to prolong the retention of high payloads at the lesions, sequester drugs from harsh environments, overcome biological barriers to exert optimal efficacy, and minimize potential side effects to guarantee bio-safety. Herein, a brief overview of the local drug delivery techniques used for ICD inducers is provided, explaining how these techniques broaden, alter, and enhance the therapeutic capability while circumventing systemic toxicity at the same time. The historical context and prominent examples of the local administration of ICD inducers are introduced. The complexities, potential pitfalls, and opportunities for local drug delivery techniques in cancer immunotherapy are also discussed.


Subject(s)
Antineoplastic Agents , Neoplasms , Humans , Pharmaceutical Preparations , Neoplasms/drug therapy , Immunogenic Cell Death , Antineoplastic Agents/pharmacology , Drug Delivery Systems , Cytotoxins/therapeutic use
2.
Data Knowl Eng ; 146: 102193, 2023 Jul.
Article in English | MEDLINE | ID: mdl-37251597

ABSTRACT

The outbreak of the COVID-19 epidemic has had a huge impact on a global scale and its impact has covered almost all human industries. The Chinese government enacted a series of policies to restrict the transportation industry in order to slow the spread of the COVID-19 virus in early 2020. With the gradual control of the COVID-19 epidemic and the reduction of confirmed cases, the Chinese transportation industry has gradually recovered. The traffic revitalization index is the main indicator for evaluating the degree of recovery of the urban transportation industry after being affected by the COVID-19 epidemic. The prediction research of traffic revitalization index can help the relevant government departments to know the state of urban traffic from the macro level and formulate relevant policies. Therefore, this study proposes a deep spatial-temporal prediction model based on tree structure for the traffic revitalization index. The model mainly includes spatial convolution module, temporal convolution module and matrix data fusion module. The spatial convolution module builds a tree convolution process based on the tree structure that can contain directional features and hierarchical features of urban nodes. The temporal convolution module constructs a deep network for capturing temporal dependent features of the data in the multi-layer residual structure. The matrix data fusion module can perform multi-scale fusion of COVID-19 epidemic data and traffic revitalization index data to further improve the prediction effect of the model. In this study, experimental comparisons between our model and multiple baseline models are conducted on real datasets. The experimental results show that our model has an average improvement of 21%, 18%, and 23% in MAE, RMSE and MAPE indicators, respectively.

3.
Pharmaceutics ; 14(7)2022 Jun 28.
Article in English | MEDLINE | ID: mdl-35890268

ABSTRACT

The lymphatic system plays an indispensable role in humoral balance, lipid metabolism, and immune regulation. The lymph nodes (LNs) are known as the primary sites of tumor metastasis and the metastatic LNs largely affected the prognosis of the patiens. A well-designed lymphatic-targeted system favors disease treatment as well as vaccination efficacy. In recent years, development of nanotechnologies and emerging biomaterials have gained increasing attention in developing lymph-node-targeted drug-delivery systems. By mimicking the endogenous macromolecules or lipid conjugates, lymph-node-targeted nanocarries hold potential for disease diagnosis and tumor therapy. This review gives an introduction to the physiological functions of LNs and the roles of LNs in diseases, followed by a review of typical lymph-node-targeted nanomaterial-based drug-delivery systems (e.g., liposomes, micelles, inorganic nanomaterials, hydrogel, and nanocapsules). Future perspectives and conclusions concerned with lymph-node-targeted drug-delivery systems are also provided.

SELECTION OF CITATIONS
SEARCH DETAIL
...